Difference between revisions of "Tissue floater"
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*Tissue that is confidently identified as a floater and benign is typically identified as such on the slide and otherwise ignored. | *Tissue that is confidently identified as a floater and benign is typically identified as such on the slide and otherwise ignored. | ||
**Example: a fragment of benign colon on an endometrial biopsy seen only on one level. | **Example: a fragment of benign colon on an endometrial biopsy seen only on one level. | ||
*Tissue that cannot be definitely identified as a floater may require identity testing, using short tanden repeat (STR) DNA testing.<ref name=pmid19745614>{{Cite journal | last1 = Mosse | first1 = CA. | last2 = Stumph | first2 = JR. | last3 = Best | first3 = DH. | last4 = Vnencak-Jones | first4 = CL. | title = A B-cell lymphoma diagnosed in floater tissue: implications of the diagnosis and resolution of a laboratory error. | journal = Am J Med Sci | volume = 338 | issue = 3 | pages = 248-51 | month = Sep | year = 2009 | doi = 10.1097/MAJ.0b013e3181a88dc0 | PMID = 19745614 }}</ref> | *Tissue that cannot be definitely identified as a floater may require [[identity testing]], using short tanden repeat (STR) DNA testing.<ref name=pmid19745614>{{Cite journal | last1 = Mosse | first1 = CA. | last2 = Stumph | first2 = JR. | last3 = Best | first3 = DH. | last4 = Vnencak-Jones | first4 = CL. | title = A B-cell lymphoma diagnosed in floater tissue: implications of the diagnosis and resolution of a laboratory error. | journal = Am J Med Sci | volume = 338 | issue = 3 | pages = 248-51 | month = Sep | year = 2009 | doi = 10.1097/MAJ.0b013e3181a88dc0 | PMID = 19745614 }}</ref> | ||
*Malignant tissue that is apparently foreign to the case should be worked-up and reported. | *Malignant tissue that is apparently foreign to the case should be worked-up and reported. | ||
Revision as of 10:59, 1 May 2014
A tissue floater, also floater, is a (biologic) contaminant that is transferred to the slide some time during tissue processing.[1]
A floater is a type of extraneous tissue and foreign to the case.[2][3] They are not found in the tissue block.[2] Contaminants in the tissue block, i.e. paraffin block, are known as "pick-up" and, generally, are assumed to result from conditions at the grossing bench.
Quality
Main article: Quality
Floaters are considered to be near-misses, as they can lead to misdiagnoses if not identified as such.[4] They are considered to be an indicator of (poor) quality.
Management
- Tissue that is confidently identified as a floater and benign is typically identified as such on the slide and otherwise ignored.
- Example: a fragment of benign colon on an endometrial biopsy seen only on one level.
- Tissue that cannot be definitely identified as a floater may require identity testing, using short tanden repeat (STR) DNA testing.[5]
- Malignant tissue that is apparently foreign to the case should be worked-up and reported.
See also
References
- ↑ Platt, E.; Sommer, P.; McDonald, L.; Bennett, A.; Hunt, J. (Jun 2009). "Tissue floaters and contaminants in the histology laboratory.". Arch Pathol Lab Med 133 (6): 973-8. doi:10.1043/1543-2165-133.6.973. PMID 19492892.
- ↑ 2.0 2.1 Layfield, LJ.; Witt, BL.; Metzger, KG.; Anderson, GM. (Nov 2011). "Extraneous tissue: a potential source for diagnostic error in surgical pathology.". Am J Clin Pathol 136 (5): 767-72. doi:10.1309/AJCP4FFSBPHAU8IU. PMID 22031316.
- ↑ Gephardt, GN.; Zarbo, RJ. (Nov 1996). "Extraneous tissue in surgical pathology: a College of American Pathologists Q-Probes study of 275 laboratories.". Arch Pathol Lab Med 120 (11): 1009-14. PMID 12049100.
- ↑ Smith, ML.; Raab, SS. (Nov 2011). "Assessment of latent factors contributing to error: addressing surgical pathology error wisely.". Arch Pathol Lab Med 135 (11): 1436-40. doi:10.5858/arpa.2011-0334-OA. PMID 22032570.
- ↑ Mosse, CA.; Stumph, JR.; Best, DH.; Vnencak-Jones, CL. (Sep 2009). "A B-cell lymphoma diagnosed in floater tissue: implications of the diagnosis and resolution of a laboratory error.". Am J Med Sci 338 (3): 248-51. doi:10.1097/MAJ.0b013e3181a88dc0. PMID 19745614.