Difference between revisions of "Peripheral nerve sheath tumours"
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*[http://commons.wikimedia.org/wiki/File:Neurofibroma_(2).jpg Neurofibroma - high mag. (WC)]. | *[http://commons.wikimedia.org/wiki/File:Neurofibroma_(2).jpg Neurofibroma - high mag. (WC)]. | ||
*[http://commons.wikimedia.org/wiki/File:Neurofibroma_(3).jpg Neurofibroma - high mag. (WC)]. | *[http://commons.wikimedia.org/wiki/File:Neurofibroma_(3).jpg Neurofibroma - high mag. (WC)]. | ||
==Malignant peripheral nerve sheath tumours== | |||
===General=== | |||
*Malignant - as the name implies. | |||
===Microscopic=== | |||
Features: | |||
*Mitoses. | |||
Image(s): | |||
*[http://www.sarctrials.org/upload/mpnstpath_35923.jpg MPNST (sarctrials.org)].<ref>URL: [http://www.sarctrials.org/SARC006MPNST http://www.sarctrials.org/SARC006MPNST]. Accessed on: 5 December 2010.</ref> | |||
==See also== | ==See also== | ||
Revision as of 04:04, 6 December 2010
Peripheral nerve sheath tumours, abbreviated PNSTs, are common in neuropathology and occasionally show-up elsewhere. A very common PNST is the schwannoma.
Classification
A classification:[1]
- Benign:
- Schwannoma.
- Neurofibroma.
- Perineurioma.
- Traumatic neuroma.
- Malignant:
- Malignant peripheral nerve sheath tumour (MPNST).
Schwannoma
General
- A common neuropathology tumour that occasionally shows-up elsewhere.
- Tumour of tissue surrounding a nerve.
- Axons adjacent to the tumour are normal... but may be compressed.
- May be a part of neurofibromatosis type 2.
Microscopic
Features:[1]
- Antoni tissue (type A and type B).
- Verocay bodies - paucinuclear area surrounded by nuclei.
- In the GI tract: classically have a peripheral lymphoid cuff.[2]
Notes:
- Tumour does not smear well.[3]
Antoni A
- Cellular.
- 'Fibrillary, polar, elongated'.
Comment: May look somewhat like scattered matchsticks.
Antoni B
- Loose microcystic tissue.
- Adjacent to Antoni A.
Micrographs:
Neurofibroma
General
- May be a part of neurofibromatosis 1.
- Composed of Schwann cells, axons, fibrous material.[1]
Microscopic
Features:[1]
- Plexiform growth pattern - "bag of worms".
Image:
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Malignant peripheral nerve sheath tumours
General
- Malignant - as the name implies.
Microscopic
Features:
- Mitoses.
Image(s):
See also
References
- ↑ 1.0 1.1 1.2 1.3 Wippold FJ, Lubner M, Perrin RJ, Lämmle M, Perry A (October 2007). "Neuropathology for the neuroradiologist: Antoni A and Antoni B tissue patterns". AJNR Am J Neuroradiol 28 (9): 1633–8. doi:10.3174/ajnr.A0682. PMID 17893219. http://www.ajnr.org/cgi/reprint/28/9/1633.
- ↑ Levy AD, Quiles AM, Miettinen M, Sobin LH (March 2005). "Gastrointestinal schwannomas: CT features with clinicopathologic correlation". AJR Am J Roentgenol 184 (3): 797–802. PMID 15728600. http://www.ajronline.org/cgi/content/full/184/3/797.
- ↑ MUN. 24 November 2010.
- ↑ URL: http://www.sarctrials.org/SARC006MPNST. Accessed on: 5 December 2010.