Difference between revisions of "Follicular dendritic cell sarcoma"

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#redirect [[Spleen#Follicular_dendritic_cell_tumour]]
'''Follicular dendritic cell sarcoma''', abbreviated '''FDCS''', is a very rare [[malignant]] tumour.
 
It is also known as '''follicular dendritic cell tumour''' (abbreviated '''FDCT'''.<ref name=pmid17515347>{{Cite journal  | last1 = Leipsic | first1 = JA. | last2 = McAdams | first2 = HP. | last3 = Sporn | first3 = TA. | title = Follicular dendritic cell sarcoma of the mediastinum. | journal = AJR Am J Roentgenol | volume = 188 | issue = 6 | pages = W554-6 | month = Jun | year = 2007 | doi = 10.2214/AJR.04.1530 | PMID = 17515347 }}</ref>
 
Other possible names are ''dendritic reticulum cell sarcoma'', (???) ''follicular dendritic cell neoplasm''. (???)
 
==General==
*Very rare.
*Behave like a low-grade sarcoma.<ref name=pmid9606805>{{Cite journal  | last1 = Perez-Ordoñez | first1 = B. | last2 = Rosai | first2 = J. | title = Follicular dendritic cell tumor: review of the entity. | journal = Semin Diagn Pathol | volume = 15 | issue = 2 | pages = 144-54 | month = May | year = 1998 | doi =  | PMID = 9606805 }}</ref>
*Reported association with [[Castleman disease]] (hyaline-vascular type).<ref name=pmid9606805/>
 
==Microscopic==
Features:<ref name=pmid9606805/>
*Oval or spindle-shaped cellular & nuclear morphology.
*Variable architecture (sheets, fascicles, whorles, storiform pattern).
*Nuclei:
**Small nucleoli.
**Clear or dispersed chromatin.
*Multinucleated cells.
*Interspersed small lymphocytes - '''distinctive feature'''.
*+/-Necrosis.
*+/-Marked nuclear atypia.
*+/-Abundant mitoses.
 
DDx:
*[[Histiocytic sarcoma]].<ref name=pmid17324277>{{Cite journal  | last1 = Alexiev | first1 = BA. | last2 = Sailey | first2 = CJ. | last3 = McClure | first3 = SA. | last4 = Ord | first4 = RA. | last5 = Zhao | first5 = XF. | last6 = Papadimitriou | first6 = JC. | title = Primary histiocytic sarcoma arising in the head and neck with predominant spindle cell component. | journal = Diagn Pathol | volume = 2 | issue =  | pages = 7 | month =  | year = 2007 | doi = 10.1186/1746-1596-2-7 | PMID = 17324277 | url = http://www.diagnosticpathology.org/content/2/1/7 }}</ref>
*[[Spindle cell lesions]].
 
===Images===
*[http://www.ajronline.org/content/188/6/W554/F7.expansion FDCS (ajronline.org)].<ref name=pmid17515347/>
*[http://www.webpathology.com/image.asp?case=391&n=1 DRCS (webpathology.com)].
*[http://path.upmc.edu/cases/case55/dx.html FDCT - several crappy images (upmc.edu)].
*[http://path.upmc.edu/cases/case399.html FDCS - several images (upmc.edu)].
 
==IHC==
Features:<ref name=pmid9606805/>
*CD21 +ve.
*CD35 +ve.
*Ki-M4p +ve
*Ki-FDRC1p +ve.
*Vimentin +ve.
 
*S-100 +ve/-ve.
*Muscle-specific actin +ve/-ve.
*EMA +ve/-ve.
 
==See also==
*[[Spleen]].
 
==References==
{{Reflist|2}}
 
[[Category:Diagnosis]]
[[Category:Spleen]]

Revision as of 11:59, 25 April 2014

Follicular dendritic cell sarcoma, abbreviated FDCS, is a very rare malignant tumour.

It is also known as follicular dendritic cell tumour (abbreviated FDCT.[1]

Other possible names are dendritic reticulum cell sarcoma, (???) follicular dendritic cell neoplasm. (???)

General

  • Very rare.
  • Behave like a low-grade sarcoma.[2]
  • Reported association with Castleman disease (hyaline-vascular type).[2]

Microscopic

Features:[2]

  • Oval or spindle-shaped cellular & nuclear morphology.
  • Variable architecture (sheets, fascicles, whorles, storiform pattern).
  • Nuclei:
    • Small nucleoli.
    • Clear or dispersed chromatin.
  • Multinucleated cells.
  • Interspersed small lymphocytes - distinctive feature.
  • +/-Necrosis.
  • +/-Marked nuclear atypia.
  • +/-Abundant mitoses.

DDx:

Images

IHC

Features:[2]

  • CD21 +ve.
  • CD35 +ve.
  • Ki-M4p +ve
  • Ki-FDRC1p +ve.
  • Vimentin +ve.
  • S-100 +ve/-ve.
  • Muscle-specific actin +ve/-ve.
  • EMA +ve/-ve.

See also

References

  1. ↑ 1.0 1.1 Leipsic, JA.; McAdams, HP.; Sporn, TA. (Jun 2007). "Follicular dendritic cell sarcoma of the mediastinum.". AJR Am J Roentgenol 188 (6): W554-6. doi:10.2214/AJR.04.1530. PMID 17515347.
  2. ↑ 2.0 2.1 2.2 2.3 Perez-Ordoñez, B.; Rosai, J. (May 1998). "Follicular dendritic cell tumor: review of the entity.". Semin Diagn Pathol 15 (2): 144-54. PMID 9606805.
  3. ↑ Alexiev, BA.; Sailey, CJ.; McClure, SA.; Ord, RA.; Zhao, XF.; Papadimitriou, JC. (2007). "Primary histiocytic sarcoma arising in the head and neck with predominant spindle cell component.". Diagn Pathol 2: 7. doi:10.1186/1746-1596-2-7. PMID 17324277. http://www.diagnosticpathology.org/content/2/1/7.
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