Difference between revisions of "Adenocarcinoma of the duodenum"
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'''Adenocarcinoma of the duodenum''' is an uncommon epithelial derived malignancy of the [[duodenum]]. It is frequently associated with [[familial adenomatous polyposis]]. | |||
It is also known as '''duodenal adenocarcinoma''', '''duodenal carcinoma''' and '''carcinoma of the duodenum'''. | |||
==General== | |||
*Duodenum - most common site in [[small bowel]]. | |||
**[[Ampulla of Vater]] most common site in the duodenum - see ''[[ampullary carcinoma]]''. | |||
Risk factors: | |||
*[[Crohn's disease]]. | |||
*[[Celiac sprue]]. | |||
*[[Familial adenomatous polyposis]] (FAP). | |||
*[[HNPCC]]. | |||
*[[Peutz-Jeghers syndrome]]. | |||
==Gross== | |||
*Mass ulcerating or exophytic. | |||
Image: | |||
<gallery> | |||
Image:Duodenal adenocarcinoma.png | Duodenal adenocarcinoma - endoscopy. (WC/Samir) | |||
</gallery> | |||
==Microscopic== | |||
Features: | |||
*Similar to large bowel adenocarcinomas - see ''[[colorectal tumours]]'' article. | |||
**May be similar to gastric adenocarcinomas (gastric-type adenocarcinoma).<ref>{{Cite journal | last1 = Kushima | first1 = R. | last2 = Stolte | first2 = M. | last3 = Dirks | first3 = K. | last4 = Vieth | first4 = M. | last5 = Okabe | first5 = H. | last6 = Borchard | first6 = F. | last7 = Hattori | first7 = T. | title = Gastric-type adenocarcinoma of the duodenal second portion histogenetically associated with hyperplasia and gastric-foveolar metaplasia of Brunner's glands. | journal = Virchows Arch | volume = 440 | issue = 6 | pages = 655-9 | month = Jun | year = 2002 | doi = 10.1007/s00428-002-0615-z | PMID = 12070607 }} | |||
</ref> | |||
DDx: | |||
*[[Ampullary carcinoma]]. | |||
*[[Duodenal neuroendocrine tumour]]. | |||
==IHC== | |||
*SMAD4 -ve/+ve.<ref name=pmid15157044>{{Cite journal | last1 = Bläker | first1 = H. | last2 = Aulmann | first2 = S. | last3 = Helmchen | first3 = B. | last4 = Otto | first4 = HF. | last5 = Rieker | first5 = RJ. | last6 = Penzel | first6 = R. | title = Loss of SMAD4 function in small intestinal adenocarcinomas: comparison of genetic and immunohistochemical findings. | journal = Pathol Res Pract | volume = 200 | issue = 1 | pages = 1-7 | month = | year = 2004 | doi = | PMID = 15157044 }}</ref> | |||
==See also== | |||
*[[Duodenum]]. | |||
*[[Adenocarcinoma]]. | |||
==References== | |||
{{Reflist|2}} | |||
[[Category:Duodenum]] | |||
[[Category:Diagnosis]] | |||
Latest revision as of 00:18, 23 April 2014
Adenocarcinoma of the duodenum is an uncommon epithelial derived malignancy of the duodenum. It is frequently associated with familial adenomatous polyposis.
It is also known as duodenal adenocarcinoma, duodenal carcinoma and carcinoma of the duodenum.
General
- Duodenum - most common site in small bowel.
- Ampulla of Vater most common site in the duodenum - see ampullary carcinoma.
Risk factors:
Gross
- Mass ulcerating or exophytic.
Image:
Duodenal adenocarcinoma - endoscopy. (WC/Samir)
Microscopic
Features:
- Similar to large bowel adenocarcinomas - see colorectal tumours article.
- May be similar to gastric adenocarcinomas (gastric-type adenocarcinoma).[1]
DDx:
IHC
- SMAD4 -ve/+ve.[2]
See also
References
- ↑ Kushima, R.; Stolte, M.; Dirks, K.; Vieth, M.; Okabe, H.; Borchard, F.; Hattori, T. (Jun 2002). "Gastric-type adenocarcinoma of the duodenal second portion histogenetically associated with hyperplasia and gastric-foveolar metaplasia of Brunner's glands.". Virchows Arch 440 (6): 655-9. doi:10.1007/s00428-002-0615-z. PMID 12070607.
- ↑ Bläker, H.; Aulmann, S.; Helmchen, B.; Otto, HF.; Rieker, RJ.; Penzel, R. (2004). "Loss of SMAD4 function in small intestinal adenocarcinomas: comparison of genetic and immunohistochemical findings.". Pathol Res Pract 200 (1): 1-7. PMID 15157044.