Difference between revisions of "Umbilical cord vasculitis"
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'''Umbilical cord vasculitis''' is a relatively common occurance in [[placenta|placental pathology]]. It is thought to preceed [[funisitis]] and is closely related to [[chorioamnionitis]]. | |||
==General== | |||
*Usually seen together with [[chorioamnionitis]]. | |||
**May be described as the ''fetal response'' to chorioamnionitis.<ref name=pmid14749651/> | |||
*Presence considered to be a good prognosticator.<ref name=pmid14749651>{{Cite journal | last1 = Lahra | first1 = MM. | last2 = Jeffery | first2 = HE. | title = A fetal response to chorioamnionitis is associated with early survival after preterm birth. | journal = Am J Obstet Gynecol | volume = 190 | issue = 1 | pages = 147-51 | month = Jan | year = 2004 | doi = 10.1016/j.ajog.2003.07.012 | PMID = 14749651 }} | |||
</ref> | |||
==Microscopic== | |||
Features: | |||
*[[Neutrophil]]s in the vessels of the umbilical cord. | |||
*Wharton's jelly without neutrophils. | |||
Notes: | |||
*Margination of neutrophils in the affected vessels is usually seen, and (in theory) precedes the development of vasculitis. | |||
*Umbilical vein involvement (umbilical phlebitis) precedes umbilical artery involvement (umbilical arteritis).<ref name=pmid21090086>{{Cite journal | last1 = Vedovato | first1 = S. | last2 = Zanardo | first2 = V. | title = [Chorioamnionitis and inflammatory disease in the premature newborn infant]. | journal = Minerva Pediatr | volume = 62 | issue = 3 Suppl 1 | pages = 155-6 | month = Jun | year = 2010 | doi = | PMID = 21090086 }}</ref> | |||
DDx: | |||
*[[Funisitis]] - neutrophils are ''also'' in the connective tissue of the umbilical cord (Wharton's jelly). | |||
===Grading=== | |||
Umbilical cord vasculitis:<ref name=Ref_Sternberg4_2311>{{Ref Sternberg4|2311}}</ref> | |||
* +0.5 for each vessel. | |||
* +0.5 for each vessel with severe involvement. | |||
===Image=== | |||
<gallery> | |||
Image:Chorial vasculitis and chorioamnionitis in AIS, HE 4.jpg |Vasculitis. (WC) | |||
</gallery> | |||
==See also== | |||
*[[Chorioamnionitis]]. | |||
==References== | |||
{{Reflist|2}} | |||
[[Category:Diagnosis]] | [[Category:Diagnosis]] | ||
[[Category:Placenta]] | |||
Revision as of 04:17, 30 March 2014
Umbilical cord vasculitis is a relatively common occurance in placental pathology. It is thought to preceed funisitis and is closely related to chorioamnionitis.
General
- Usually seen together with chorioamnionitis.
- May be described as the fetal response to chorioamnionitis.[1]
- Presence considered to be a good prognosticator.[1]
Microscopic
Features:
- Neutrophils in the vessels of the umbilical cord.
- Wharton's jelly without neutrophils.
Notes:
- Margination of neutrophils in the affected vessels is usually seen, and (in theory) precedes the development of vasculitis.
- Umbilical vein involvement (umbilical phlebitis) precedes umbilical artery involvement (umbilical arteritis).[2]
DDx:
- Funisitis - neutrophils are also in the connective tissue of the umbilical cord (Wharton's jelly).
Grading
Umbilical cord vasculitis:[3]
- +0.5 for each vessel.
- +0.5 for each vessel with severe involvement.
Image
Vasculitis. (WC)
See also
References
- ↑ 1.0 1.1 Lahra, MM.; Jeffery, HE. (Jan 2004). "A fetal response to chorioamnionitis is associated with early survival after preterm birth.". Am J Obstet Gynecol 190 (1): 147-51. doi:10.1016/j.ajog.2003.07.012. PMID 14749651.
- ↑ Vedovato, S.; Zanardo, V. (Jun 2010). "[Chorioamnionitis and inflammatory disease in the premature newborn infant].". Minerva Pediatr 62 (3 Suppl 1): 155-6. PMID 21090086.
- ↑ Mills, Stacey E; Carter, Darryl; Greenson, Joel K; Oberman, Harold A; Reuter, Victor E (2004). Sternberg's Diagnostic Surgical Pathology (4th ed.). Lippincott Williams & Wilkins. pp. 2311. ISBN 978-0781740517.