Classic vulvar intraepithelial neoplasia: Difference between revisions
Jump to navigation
Jump to search
images |
|||
| (2 intermediate revisions by the same user not shown) | |||
| Line 4: | Line 4: | ||
| Width = | | Width = | ||
| Caption = Classic vulvar intraepithelial neoplasia. [[H&E stain]]. | | Caption = Classic vulvar intraepithelial neoplasia. [[H&E stain]]. | ||
| Synonyms = | | Synonyms = usual vulvar intraepithelial neoplasia | ||
| Micro = increased [[NC ratio]], multinucleation, lack of maturation to surface (not very useful -- unlike in the cervix), +/-non-basal mitoses, +/-atypical mitoses | | Micro = increased [[NC ratio]], multinucleation, lack of maturation to surface (not very useful -- unlike in the cervix), +/-non-basal mitoses, +/-atypical mitoses | ||
| Subtypes = | | Subtypes = | ||
| Line 86: | Line 86: | ||
- NEGATIVE FOR INVASIVE MALIGNANCY. | - NEGATIVE FOR INVASIVE MALIGNANCY. | ||
</pre> | </pre> | ||
====VIN II==== | |||
<pre> | |||
LEFT LABIUM MINUS, PUNCH BIOPSY: | |||
- CLASSIC VULVAR INTRAEPITHELIAL NEOPLASIA (cVIN) II (MODERATE DYSPLASIA). | |||
- LICHEN SCLEROSUS. | |||
COMMENT: | |||
Immunostains: | |||
POSITIVE: p16 (strong, diffuse - lower 2/3 of the epithelium). | |||
NEGATIVE: HMB-45, S-100, p53 (weak, patchy, superficial squamous cells). | |||
PROLIFERATION (Ki-67): increased, marks superficial squamous cells (compatible with | |||
high-grade lesion). | |||
</pre> | |||
=====Micro===== | |||
The sections show a punch biopsy of skin. Compact hyperkeratosis and hypergranulosis is | |||
present. The epidermis is edematous, has moderately atypical cells in the lower two thirds | |||
of the epithelium and mitotic activity. Several suprabasal mitoses are present. Apoptotic | |||
keratinocytes are present. Granular yellow pigment (hemosiderin?) is present in the | |||
epidermis. The epidermis is not significantly thickened. The lesional cells extend | |||
to the lateral edges of the tissue. | |||
====VIN III==== | ====VIN III==== | ||