Difference between revisions of "Fibrous dysplasia"

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#redirect [[Bone#Fibrous_dysplasia]]
{{ Infobox diagnosis
| Name      = {{PAGENAME}}
| Image      = Fibrous_dysplasia_-_intermed_mag.jpg
| Width      =
| Caption    = Fibrous dysplasia. [[H&E stain]].
| Synonyms  =
| Micro      = woven bone with odd irregular shapes (often described as "chinese characters"), fibrous tissue around bone, no osteoblastic rimming
| Subtypes  =
| LMDDx      = [[desmoplastic fibroma]], low-grade [[fibrosarcoma]], [[low-grade central osteosarcoma]]
| Stains    =
| IHC        =
| EM        =
| Molecular  =
| IF        =
| Gross      =
| Grossing  =
| Site      = [[bone]]
| Assdx      =
| Syndromes  =
| Clinicalhx =
| Signs      =
| Symptoms  =
| Prevalence = uncommon
| Bloodwork  =
| Rads      =
| Endoscopy  =
| Prognosis  = benign
| Other      =
| ClinDDx    =
| Tx        =
}}
'''Fibrous dysplasia''', also '''osteitis fibrosa''', is a rare disorder of [[bone]] that has a distinctive microscopic appearance.


==General==
Classification:
*''Monostotic'' - one bone involved, ~80% of cases.
*''Polyostotic'' - several bones involved, ~20% of cases.
**May be associated with [[McCune-Albright syndrome]].
==Microscopic==
Features:<ref>URL: [http://www.pathologypics.com/pictview.aspx?id=104 http://www.pathologypics.com/pictview.aspx?id=104]. Accessed on: 14 April 2011.</ref>
*Woven bone with odd irregular shapes - '''key feature'''.
**Described as "chinese characters".<ref>URL: [http://www.pathcases.com/bone_tumors_and_tumor.htm http://www.pathcases.com/bone_tumors_and_tumor.htm]. Accessed on: 31 May 2011.</ref>
*Fibrous tissue around bone.
Notes:
*No osteoblastic rimming.
DDx:
*[[Desmoplastic fibroma]] - has lamellar bone.
*Low grade [[fibrosarcoma]].
*[[Low-grade central osteosarcoma]].<ref name=inwards>{{cite journal |author=Inwards, CY |title=Low-grade central osteosarcoma versus fibrous dysplasia |journal=Pathology Case Reviews |volume=6 |issue=1 |pages=22-27 |year=2001 |pmid= |doi= |url= http://journals.lww.com/pathologycasereviews/Fulltext/2001/01000/Low_Grade_Central_Osteosarcoma_Versus_Fibrous.5.aspx }}</ref>
===Images===
<gallery>
Image:Fibrous_dysplasia_-_low_mag.jpg | Fibrous dysplasia - low mag. (WC/Nephron)
Image:Fibrous_dysplasia_-_intermed_mag.jpg | Fibrous dysplasia - intermed. mag. (WC/Nephron)
Image:Fibrous_dysplasia_-_high_mag.jpg | Fibrous dysplasia - high mag. (WC/Nephron)
</gallery>
www:
*[http://www.pathologypics.com/pictview.aspx?id=104 Fibrous dysplasia of bone - high mag. (pathologypics.com)].
*[http://www.pathologypics.com/BigPicViewer.aspx?PictureID=103 Fibrous dysplasia of bone - low mag. (pathologypics.com)].
==See also==
*[[Bone]].
==References==
{{Reflist|2}}
[[Category:Bone]]
[[Category:Diagnosis]]
[[Category:Diagnosis]]

Revision as of 02:50, 25 February 2014

Fibrous dysplasia
Diagnosis in short

Fibrous dysplasia. H&E stain.

LM woven bone with odd irregular shapes (often described as "chinese characters"), fibrous tissue around bone, no osteoblastic rimming
LM DDx desmoplastic fibroma, low-grade fibrosarcoma, low-grade central osteosarcoma
Site bone

Prevalence uncommon
Prognosis benign

Fibrous dysplasia, also osteitis fibrosa, is a rare disorder of bone that has a distinctive microscopic appearance.

General

Classification:

  • Monostotic - one bone involved, ~80% of cases.
  • Polyostotic - several bones involved, ~20% of cases.

Microscopic

Features:[1]

  • Woven bone with odd irregular shapes - key feature.
    • Described as "chinese characters".[2]
  • Fibrous tissue around bone.

Notes:

  • No osteoblastic rimming.

DDx:

Images

www:

See also

References