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Difference between revisions of "Neuropathology tumours"
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Neuropathology tumours (view source)
Revision as of 05:11, 23 November 2010
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===General=== | ===General=== | ||
*Mostly paediatric population. | *Mostly paediatric population. | ||
*May be seen as a component of [[Nevoid basal cell carcinoma syndrome]] (NBCCS). | |||
===Gross=== | |||
*Location: cerebellum - '''key feature'''. | |||
**Morphologically identical supratentorial tumours are called ''primitive neuroepithelial tumour'' (PNET). | |||
===Microscopic=== | ===Microscopic=== | ||
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Notes: | Notes: | ||
*Prognosis:<ref name=pmid18841049>{{cite journal |author=Gulino A, Arcella A, Giangaspero F |title=Pathological and molecular heterogeneity of medulloblastoma |journal=Curr Opin Oncol |volume=20 |issue=6 |pages=668–75 |year=2008 |month=November |pmid=18841049 |doi=10.1097/CCO.0b013e32831369f4 |url=}}</ref><ref name=pmid20940197>{{cite journal |author=Rutkowski S, von Hoff K, Emser A, ''et al.'' |title=Survival and Prognostic Factors of Early Childhood Medulloblastoma: An International Meta-Analysis |journal=J Clin Oncol |volume=28 |issue=33 |pages=4961–4968 |year=2010 |month=November |pmid=20940197 |doi=10.1200/JCO.2010.30.2299 |url=}}</ref> DNMB & MBEN > classic > anaplastic variant, large cell variant. | *Prognosis:<ref name=pmid18841049>{{cite journal |author=Gulino A, Arcella A, Giangaspero F |title=Pathological and molecular heterogeneity of medulloblastoma |journal=Curr Opin Oncol |volume=20 |issue=6 |pages=668–75 |year=2008 |month=November |pmid=18841049 |doi=10.1097/CCO.0b013e32831369f4 |url=}}</ref><ref name=pmid20940197>{{cite journal |author=Rutkowski S, von Hoff K, Emser A, ''et al.'' |title=Survival and Prognostic Factors of Early Childhood Medulloblastoma: An International Meta-Analysis |journal=J Clin Oncol |volume=28 |issue=33 |pages=4961–4968 |year=2010 |month=November |pmid=20940197 |doi=10.1200/JCO.2010.30.2299 |url=}}</ref> DNMB & MBEN > classic > anaplastic variant, large cell variant. | ||
=====Anaplastic variant===== | |||
Features: | |||
*Larger cells. | |||
*Severe anaplasia. | |||
*Polygonal cells. | |||
==Primitive neuroepithelial tumour== | |||
===General=== | |||
*Abbreviated ''PNET''. | |||
===Microscopic=== | |||
Features: | |||
*See ''medulloblastoma''. | |||
DDx: Embryonal tumor with abundant neuropil and true rosettes (ETANTR).<ref>{{cite journal |author=Buccoliero AM, Castiglione F, Degl'Innocenti DR, ''et al.'' |title=Embryonal tumor with abundant neuropil and true rosettes: morphological, immunohistochemical, ultrastructural and molecular study of a case showing features of medulloepithelioma and areas of mesenchymal and epithelial differentiation |journal=Neuropathology |volume=30 |issue=1 |pages=84–91 |year=2010 |month=February |pmid=19563506 |doi=10.1111/j.1440-1789.2009.01040.x |url=}}</ref> | |||
==See also== | ==See also== | ||