Difference between revisions of "Papillary urothelial hyperplasia"

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'''Papillary urothelial hyperplasia''' is a benign lesion of the [[urothelium]] that is associated with the subsequent development of low-grade papillary urothelial carcinoma.
'''Papillary urothelial hyperplasia''' is a benign lesion of the [[urothelium]] that is associated with the subsequent development of low-grade papillary urothelial carcinoma.


===General===
==General==
*Benign.
*Benign.
*Strong association with papillary neoplasms.
*Strong association with papillary neoplasms.
**On follow-up, in one study, >1/3 have a neoplasm; thus, follow-up is recommended.<ref name=pmid20438409>{{Cite journal  | last1 = Readal | first1 = N. | last2 = Epstein | first2 = JI. | title = Papillary urothelial hyperplasia: relationship to urothelial neoplasms. | journal = Pathology | volume = 42 | issue = 4 | pages = 360-3 | month = Jun | year = 2010 | doi = 10.3109/00313021003767322 | PMID = 20438409 }}</ref>
**On follow-up, in one study, >1/3 have a neoplasm; thus, follow-up is recommended.<ref name=pmid20438409>{{Cite journal  | last1 = Readal | first1 = N. | last2 = Epstein | first2 = JI. | title = Papillary urothelial hyperplasia: relationship to urothelial neoplasms. | journal = Pathology | volume = 42 | issue = 4 | pages = 360-3 | month = Jun | year = 2010 | doi = 10.3109/00313021003767322 | PMID = 20438409 }}</ref>


===Microscopic===
==Microscopic==
Features:<ref>URL: [http://pathology.jhu.edu/bladder/definitions.cfm http://pathology.jhu.edu/bladder/definitions.cfm]. Accessed on: 27 January 2014.</ref>
Features:<ref>URL: [http://pathology.jhu.edu/bladder/definitions.cfm http://pathology.jhu.edu/bladder/definitions.cfm]. Accessed on: 27 January 2014.</ref>
*Inflammation.
*Inflammation.
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*No urothelial cell atypia.
*No urothelial cell atypia.


Image:
DDx:
*[[Low-grade papillary urothelial carcinoma]].
*[[PUNLMP]].
*[[Urothelial papilloma]].
 
===Image===
*[http://pathology.jhu.edu/bladder/image1.cfm?case_number=2&image_number=1 Papillary hyperplasia (jhu.edu)].
*[http://pathology.jhu.edu/bladder/image1.cfm?case_number=2&image_number=1 Papillary hyperplasia (jhu.edu)].


===Sign out===
==Sign out==
<pre>
<pre>
URINARY BLADDER, BIOPSY:
URINARY BLADDER, BIOPSY:

Revision as of 19:27, 27 January 2014

Papillary urothelial hyperplasia is a benign lesion of the urothelium that is associated with the subsequent development of low-grade papillary urothelial carcinoma.

General

  • Benign.
  • Strong association with papillary neoplasms.
    • On follow-up, in one study, >1/3 have a neoplasm; thus, follow-up is recommended.[1]

Microscopic

Features:[2]

  • Inflammation.
  • Rare papillae
    • Do not have a well-developed fibrovascular core.
  • No urothelial cell atypia.

DDx:

Image

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URINARY BLADDER, BIOPSY:
- REACTIVE PAPILLARY HYPERPLASIA, SEE COMMENT.
- NO MUSCULARIS PROPRIA IDENTIFIED.
- CYSTITIS CYSTICA ET GLANDULARIS.
- NO EVIDENCE OF MALIGNANCY.

COMMENT:
The urothelial forms rare papillary structures; these are interpreted as reactive.

The urothelium stains as follow:
CK7: positive (patchy).
CK20: very rare superficial cells (normal).
Ki-67: rare, focally increased, negative in papillary structures (<10%).
p53: negative (weak focal <20%), very rare weak in rare papillary structures (<5%).

Follow-up is recommended.

See also

References

  1. Readal, N.; Epstein, JI. (Jun 2010). "Papillary urothelial hyperplasia: relationship to urothelial neoplasms.". Pathology 42 (4): 360-3. doi:10.3109/00313021003767322. PMID 20438409.
  2. URL: http://pathology.jhu.edu/bladder/definitions.cfm. Accessed on: 27 January 2014.