Difference between revisions of "Papillary urothelial hyperplasia"
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'''Papillary urothelial hyperplasia''' is a benign lesion of the [[urothelium]] that is associated with the subsequent development of low-grade papillary urothelial carcinoma. | '''Papillary urothelial hyperplasia''' is a benign lesion of the [[urothelium]] that is associated with the subsequent development of low-grade papillary urothelial carcinoma. | ||
==General== | |||
*Benign. | *Benign. | ||
*Strong association with papillary neoplasms. | *Strong association with papillary neoplasms. | ||
**On follow-up, in one study, >1/3 have a neoplasm; thus, follow-up is recommended.<ref name=pmid20438409>{{Cite journal | last1 = Readal | first1 = N. | last2 = Epstein | first2 = JI. | title = Papillary urothelial hyperplasia: relationship to urothelial neoplasms. | journal = Pathology | volume = 42 | issue = 4 | pages = 360-3 | month = Jun | year = 2010 | doi = 10.3109/00313021003767322 | PMID = 20438409 }}</ref> | **On follow-up, in one study, >1/3 have a neoplasm; thus, follow-up is recommended.<ref name=pmid20438409>{{Cite journal | last1 = Readal | first1 = N. | last2 = Epstein | first2 = JI. | title = Papillary urothelial hyperplasia: relationship to urothelial neoplasms. | journal = Pathology | volume = 42 | issue = 4 | pages = 360-3 | month = Jun | year = 2010 | doi = 10.3109/00313021003767322 | PMID = 20438409 }}</ref> | ||
==Microscopic== | |||
Features:<ref>URL: [http://pathology.jhu.edu/bladder/definitions.cfm http://pathology.jhu.edu/bladder/definitions.cfm]. Accessed on: 27 January 2014.</ref> | Features:<ref>URL: [http://pathology.jhu.edu/bladder/definitions.cfm http://pathology.jhu.edu/bladder/definitions.cfm]. Accessed on: 27 January 2014.</ref> | ||
*Inflammation. | *Inflammation. | ||
| Line 13: | Line 13: | ||
*No urothelial cell atypia. | *No urothelial cell atypia. | ||
Image | DDx: | ||
*[[Low-grade papillary urothelial carcinoma]]. | |||
*[[PUNLMP]]. | |||
*[[Urothelial papilloma]]. | |||
===Image=== | |||
*[http://pathology.jhu.edu/bladder/image1.cfm?case_number=2&image_number=1 Papillary hyperplasia (jhu.edu)]. | *[http://pathology.jhu.edu/bladder/image1.cfm?case_number=2&image_number=1 Papillary hyperplasia (jhu.edu)]. | ||
==Sign out== | |||
<pre> | <pre> | ||
URINARY BLADDER, BIOPSY: | URINARY BLADDER, BIOPSY: | ||
Revision as of 19:27, 27 January 2014
Papillary urothelial hyperplasia is a benign lesion of the urothelium that is associated with the subsequent development of low-grade papillary urothelial carcinoma.
General
- Benign.
- Strong association with papillary neoplasms.
- On follow-up, in one study, >1/3 have a neoplasm; thus, follow-up is recommended.[1]
Microscopic
Features:[2]
- Inflammation.
- Rare papillae
- Do not have a well-developed fibrovascular core.
- No urothelial cell atypia.
DDx:
Image
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URINARY BLADDER, BIOPSY: - REACTIVE PAPILLARY HYPERPLASIA, SEE COMMENT. - NO MUSCULARIS PROPRIA IDENTIFIED. - CYSTITIS CYSTICA ET GLANDULARIS. - NO EVIDENCE OF MALIGNANCY. COMMENT: The urothelial forms rare papillary structures; these are interpreted as reactive. The urothelium stains as follow: CK7: positive (patchy). CK20: very rare superficial cells (normal). Ki-67: rare, focally increased, negative in papillary structures (<10%). p53: negative (weak focal <20%), very rare weak in rare papillary structures (<5%). Follow-up is recommended.
See also
References
- ↑ Readal, N.; Epstein, JI. (Jun 2010). "Papillary urothelial hyperplasia: relationship to urothelial neoplasms.". Pathology 42 (4): 360-3. doi:10.3109/00313021003767322. PMID 20438409.
- ↑ URL: http://pathology.jhu.edu/bladder/definitions.cfm. Accessed on: 27 January 2014.