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Difference between revisions of "Synovial sarcoma"
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*[http://www.tumorlibrary.com/case/detail.jsp?image_id=2462 SS (tumorlibrary.com)]. | *[http://www.tumorlibrary.com/case/detail.jsp?image_id=2462 SS (tumorlibrary.com)]. | ||
==Microscopic== | |||
Comes in three (histologic) flavours:<ref name=Ref_WMSP627>{{Ref WMSP|627}}</ref><ref>{{cite journal |author=Schaal CH, Navarro FC, Moraes Neto FA |title=Primary renal sarcoma with morphologic and immunohistochemical aspects compatible with synovial sarcoma |journal=Int Braz J Urol |volume=30 |issue=3 |pages=210–3 |year=2004 |pmid=15689250 |doi= |url=http://www.brazjurol.com.br/may_june_2004/Schaal_ing_210_213.htm}}</ref> | Comes in three (histologic) flavours:<ref name=Ref_WMSP627>{{Ref WMSP|627}}</ref><ref>{{cite journal |author=Schaal CH, Navarro FC, Moraes Neto FA |title=Primary renal sarcoma with morphologic and immunohistochemical aspects compatible with synovial sarcoma |journal=Int Braz J Urol |volume=30 |issue=3 |pages=210–3 |year=2004 |pmid=15689250 |doi= |url=http://www.brazjurol.com.br/may_june_2004/Schaal_ing_210_213.htm}}</ref> | ||
#Spindle cell sarcoma with features of hemangiopericytoma, i.e. [[staghorn vessels]]. | #Spindle cell sarcoma with features of hemangiopericytoma, i.e. [[staghorn vessels]]. | ||
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**Can be difficult. | **Can be difficult. | ||
===Images=== | |||
<gallery> | <gallery> | ||
Image:Monophasic_synovial_sarcoma_-_intermed_mag.jpg | Monophasic synovial sarcoma with staghorn vessels - intermed. mag. (WC/Nephron) | Image:Monophasic_synovial_sarcoma_-_intermed_mag.jpg | Monophasic synovial sarcoma with staghorn vessels - intermed. mag. (WC/Nephron) | ||
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*[http://radiographics.rsna.org/content/26/5/1543.long Monophasic SS (radiographics.rsna.org)]. | *[http://radiographics.rsna.org/content/26/5/1543.long Monophasic SS (radiographics.rsna.org)]. | ||
==IHC== | |||
Features:<ref name=Ref_WMSP627>{{Ref WMSP|627}}</ref> | Features:<ref name=Ref_WMSP627>{{Ref WMSP|627}}</ref> | ||
*Vimentin +ve. | *Vimentin +ve. | ||
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*PGP in ''PGP9.5'' = protein gene product.<ref name=pmid6343558>{{Cite journal | last1 = Doran | first1 = JF. | last2 = Jackson | first2 = P. | last3 = Kynoch | first3 = PA. | last4 = Thompson | first4 = RJ. | title = Isolation of PGP 9.5, a new human neurone-specific protein detected by high-resolution two-dimensional electrophoresis. | journal = J Neurochem | volume = 40 | issue = 6 | pages = 1542-7 | month = Jun | year = 1983 | doi = | PMID = 6343558 }}</ref> | *PGP in ''PGP9.5'' = protein gene product.<ref name=pmid6343558>{{Cite journal | last1 = Doran | first1 = JF. | last2 = Jackson | first2 = P. | last3 = Kynoch | first3 = PA. | last4 = Thompson | first4 = RJ. | title = Isolation of PGP 9.5, a new human neurone-specific protein detected by high-resolution two-dimensional electrophoresis. | journal = J Neurochem | volume = 40 | issue = 6 | pages = 1542-7 | month = Jun | year = 1983 | doi = | PMID = 6343558 }}</ref> | ||
==EM== | |||
Features:<ref name=pmid9930576>{{Cite journal | last1 = Fisher | first1 = C. | title = Synovial sarcoma. | journal = Ann Diagn Pathol | volume = 2 | issue = 6 | pages = 401-21 | month = Dec | year = 1998 | doi = | PMID = 9930576 }}</ref> | Features:<ref name=pmid9930576>{{Cite journal | last1 = Fisher | first1 = C. | title = Synovial sarcoma. | journal = Ann Diagn Pathol | volume = 2 | issue = 6 | pages = 401-21 | month = Dec | year = 1998 | doi = | PMID = 9930576 }}</ref> | ||
*Biphasic tumour have biphasic ultrastructural features (unlike spindle cell carcinoma and [[epithelioid sarcoma]]). | *Biphasic tumour have biphasic ultrastructural features (unlike spindle cell carcinoma and [[epithelioid sarcoma]]). | ||
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**No intermediate filaments, no myofilaments. | **No intermediate filaments, no myofilaments. | ||
==Molecular pathology== | |||
Associated [[translocation]]: | Associated [[translocation]]: | ||
*t(X;18)(p11.2;q11.2).<ref>URL: [http://www.ncbi.nlm.nih.gov/omim/300813 http://www.ncbi.nlm.nih.gov/omim/300813]. Accessed on: 30 May 2010.</ref> | *t(X;18)(p11.2;q11.2).<ref>URL: [http://www.ncbi.nlm.nih.gov/omim/300813 http://www.ncbi.nlm.nih.gov/omim/300813]. Accessed on: 30 May 2010.</ref> | ||