Difference between revisions of "Talk:Neuropathology"
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==CADASIL== | ==CADASIL== | ||
===Microscopic=== | ===Microscopic=== | ||
The | The biopsy, containing epidermis, dermis and subcutaneous tissue, is technically satisfactory. Immunostains utilizing a monoclonal antibody 1E4 (anti-Notch-3) at dilution 1:50 shows the absence of granular deposits in the walls of small arteries and veins in the dermis and subcutaneous tissue. Immunostains are strongly positive on positive control tissue from a patient known to have CADASIL. | ||
===Final diagnosis=== | ===Final diagnosis=== | ||
SKIN, BIOPSY: | SKIN, BIOPSY: | ||
<br> - | <br>- ABSENCE OF NOTCH-3 IMMUNOSTAINING. | ||
Revision as of 14:28, 17 November 2010
AVM
Microscopic
The section shows numerous large veins that have thickened walls and arteries with intervening brain parenchyma. There is a small focus of monocytoid cells, hemosiderin-laden macrophages and necrosis consistent with prior bleeding.
Diagnosis
BRAIN, RIGHT TEMPORAL:
- ARTERIOVENOUS MALFORMATION.
- NEGATIVE FOR MALIGNANCY.
CADASIL
Microscopic
The biopsy, containing epidermis, dermis and subcutaneous tissue, is technically satisfactory. Immunostains utilizing a monoclonal antibody 1E4 (anti-Notch-3) at dilution 1:50 shows the absence of granular deposits in the walls of small arteries and veins in the dermis and subcutaneous tissue. Immunostains are strongly positive on positive control tissue from a patient known to have CADASIL.
Final diagnosis
SKIN, BIOPSY:
- ABSENCE OF NOTCH-3 IMMUNOSTAINING.