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Difference between revisions of "Basics"
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→Basic pathologic DDx of malignancy: expand
(→Granular crap DDx: +stains) |
(→Basic pathologic DDx of malignancy: expand) |
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| Line 59: | Line 59: | ||
Notes: | Notes: | ||
*''Melanoma'', i.e. ''malignant melanoma'', is a separate category as it can look like almost anything under the microscope. | *''Melanoma'', i.e. ''malignant melanoma'', is a separate category as it can look like almost anything under the microscope. | ||
*''Lymphoma'' includes leukemia. | |||
Factors to consider when attempting to group by morphology: | Factors to consider when attempting to group by morphology: | ||
#Cell cohesion - dyscohesive vs. cohesive. | #Cell cohesion - dyscohesive vs. cohesive. | ||
#*If one sees several groups of 5+ cells... probably cohesive. | #*If one sees several groups of 5+ cells... probably cohesive. | ||
#*Presence of cell cohesion strongly disfavours lymphoma. | |||
#Cell size - in relation to a neutrophil or red blood cell. | #Cell size - in relation to a neutrophil or red blood cell. | ||
#Cytoplasm - abundance (scant, moderate, abundant). | #Cytoplasm - abundance (scant, moderate, abundant). | ||
#*Eosinophilic cytoplasm disfavours lymphoma. | |||
#Chromatin - coarseness (fine, granular). | #Chromatin - coarseness (fine, granular). | ||
#Nucleoli - number (absent, present, multiple). | |||
#*Large nucleoli (nucleoli seen with the 10x objective) pretty much exclude neuroendocrine. | |||
Probable category by morphology: | Probable category by morphology: | ||