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Difference between revisions of "Thrombotic microangiopathy"
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Thrombotic microangiopathy (view source)
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'''Thrombotic microangiopathy''', abbreviated '''TMA''', is a group of disorders affecting small blood vessels. ''Microangiopathic'' is a disease affecting small blood vessels.<ref>URL: [http://www.mercksource.com/pp/us/cns/cns_hl_dorlands_split.jsp?pg=/ppdocs/us/common/dorlands/dorland/one/000005089.htm http://www.mercksource.com/pp/us/cns/cns_hl_dorlands_split.jsp?pg=/ppdocs/us/common/dorlands/dorland/one/000005089.htm]. Accessed on: 9 September 2010.</ref> | {{ Infobox diagnosis | ||
| Name = {{PAGENAME}} | |||
| Image = Acute thrombotic microangiopathy - very high mag.jpg | |||
| Width = | |||
| Caption = Acute thrombotic microangiopathy. [[H&E stain]]. | |||
| Synonyms = | |||
| Micro = microvascular occlusion with "loose" intimal thickening - fluffy appearing intima, fibrin entrapped RBCs, +/-onion skin-like appearance (chronic change) | |||
| Subtypes = acute, chronic | |||
| LMDDx = [[vasculitis]], small vessel | |||
| Stains = | |||
| IHC = | |||
| EM = | |||
| Molecular = | |||
| IF = | |||
| Gross = | |||
| Grossing = | |||
| Site = [[blood vessels]] - esp. [[kidney]] | |||
| Assdx = | |||
| Syndromes = | |||
| Clinicalhx = | |||
| Signs = | |||
| Symptoms = | |||
| Prevalence = | |||
| Bloodwork = | |||
| Rads = | |||
| Endoscopy = | |||
| Prognosis = | |||
| Other = | |||
| ClinDDx = DDx for TMA: [[malignant hypertension]], [[DIC]], [[APLA]] in [[SLE]], [[scleroderma]] renal crisis, [[HIV]] associated [[TTP]], reaction to chemotherapy, [[calcineurin inhibitor toxicity]] | |||
| Tx = dependent on underlying cause | |||
}} | |||
'''Thrombotic microangiopathy''', abbreviated '''TMA''', is a group of disorders affecting small blood vessels. ''Microangiopathic'' is a disease affecting small [[blood vessels]].<ref>URL: [http://www.mercksource.com/pp/us/cns/cns_hl_dorlands_split.jsp?pg=/ppdocs/us/common/dorlands/dorland/one/000005089.htm http://www.mercksource.com/pp/us/cns/cns_hl_dorlands_split.jsp?pg=/ppdocs/us/common/dorlands/dorland/one/000005089.htm]. Accessed on: 9 September 2010.</ref> | |||
==Differential diagnosis== | ==Differential diagnosis== | ||
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*Early finding: endothelial cell swelling. | *Early finding: endothelial cell swelling. | ||
Images | ===Images=== | ||
www: | |||
*[http://www.nature.com/ki/journal/v60/n3/fig_tab/4492492f5.html Thrombotic microangiopathy (nature.com)].<ref name=pmid11532079>{{Cite journal | last1 = Ruggenenti | first1 = P. | last2 = Noris | first2 = M. | last3 = Remuzzi | first3 = G. | title = Thrombotic microangiopathy, hemolytic uremic syndrome, and thrombotic thrombocytopenic purpura. | journal = Kidney Int | volume = 60 | issue = 3 | pages = 831-46 | month = Sep | year = 2001 | doi = 10.1046/j.1523-1755.2001.060003831.x | PMID = 11532079 }}</ref> | |||
*[http://path.upmc.edu/cases/case683.html Probable APLA syndrome - several images (upmc.edu)]. | |||
Acute changes: | |||
<gallery> | |||
Image: Acute thrombotic microangiopathy - high mag.jpg | High mag. | |||
Image: Acute thrombotic microangiopathy - very high mag.jpg | Very high mag. | |||
Image: Acute thrombotic microangiopathy - pas - high mag.jpg | High mag. | |||
Image: Acute thrombotic microangiopathy - pas - very high mag.jpg | Very high mag. | |||
</gallery> | |||
Chronic changes: | |||
<gallery> | |||
Image: Thrombotic microangiopathy - intermed mag.jpg | Intermed. mag. | |||
Image: Thrombotic microangiopathy - high mag.jpg | High mag. | |||
Image: Thrombotic microangiopathy - very high mag.jpg | Very high mag. | |||
</gallery> | |||
==See also== | ==See also== | ||