Cat scratch disease: Difference between revisions
Jump to navigation
Jump to search
split-out |
No edit summary |
||
| (4 intermediate revisions by the same user not shown) | |||
| Line 1: | Line 1: | ||
{{ Infobox diagnosis | |||
| Name = {{PAGENAME}} | |||
| Image = Cat_scratch_disease_-_low_mag.jpg | |||
| Width = | |||
| Caption = Cat scratch disease. [[H&E stain]]. | |||
| Micro = necrotizing granulomas with neutrophils and star-shaped (stellate), +/-multinucleated giant cells, microorganisms consistent with ''B. henselae'' | |||
| Subtypes = | |||
| LMDDx = [[sporotrichosis]], [[lymphogranuloma venereum]], [[tularemia]] | |||
| Stains = [[Warthin-Starry stain]] +ve | |||
| IHC = B. henselae +ve | |||
| EM = | |||
| Molecular = | |||
| IF = | |||
| Gross = | |||
| Grossing = | |||
| Site = [[lymph node]] - see ''[[lymph node pathology]]'' | |||
| Assdx = | |||
| Syndromes = | |||
| Clinicalhx = contact with cats | |||
| Signs = fever, lymphadenopathy | |||
| Symptoms = | |||
| Prevalence = rare | |||
| Bloodwork = | |||
| Rads = | |||
| Endoscopy = | |||
| Prognosis = benign | |||
| Other = | |||
| ClinDDx = other causes of lymphadenopathy, e.g. [[lymphoma]] | |||
}} | |||
'''Cat scratch disease''', also '''cat scratch fever''', is an uncommon [[lymph node pathology|pathology of the lymph node]]. | '''Cat scratch disease''', also '''cat scratch fever''', is an uncommon [[lymph node pathology|pathology of the lymph node]]. | ||
==General== | ==General== | ||
*Infection caused ''[[Bartonella henselae]]'',<ref name=pmid19332922>{{Cite journal | last1 = Jerris | first1 = RC. | last2 = Regnery | first2 = RL. | title = Will the real agent of cat-scratch disease please stand up? | journal = Annu Rev Microbiol | volume = 50 | issue = | pages = 707-25 | month = | year = 1996 | doi = 10.1146/annurev.micro.50.1.707 | PMID = 8905096 }}</ref> a gram-negative | *Infection caused ''[[Bartonella henselae]]'',<ref name=pmid19332922>{{Cite journal | last1 = Jerris | first1 = RC. | last2 = Regnery | first2 = RL. | title = Will the real agent of cat-scratch disease please stand up? | journal = Annu Rev Microbiol | volume = 50 | issue = | pages = 707-25 | month = | year = 1996 | doi = 10.1146/annurev.micro.50.1.707 | PMID = 8905096 }}</ref> a gram-negative bacillus (0.3-1.0 x 0.6-3.0 micrometers) in chains, clumps, or singular.<ref name=Ref_ILNP110>{{Ref ILNP|110}}</ref> | ||
*Treatment: antibiotics. | *Treatment: antibiotics. | ||
==Clinical== | ===Clinical=== | ||
Features:<ref name=Ref_ILNP113>{{Ref ILNP|113}}</ref> | Features:<ref name=Ref_ILNP113>{{Ref ILNP|113}}</ref> | ||
*Usually unilateral. | *Usually unilateral lymphadenopathy. | ||
**May be disseminated in individuals with immune dysfunction. | **May be disseminated in individuals with immune dysfunction. | ||
*Contact with cats. | *Contact with cats. | ||
==Gross== | |||
*Lymphadenopathy - usu. unlitateral. | |||
**Typically axillary or cervical (like [[tularemia]]).<ref name=pmid22706525>{{Cite journal | last1 = Asano | first1 = S. | title = Granulomatous lymphadenitis. | journal = J Clin Exp Hematop | volume = 52 | issue = 1 | pages = 1-16 | month = | year = 2012 | doi = | PMID = 22706525 }}</ref> | |||
==Micrograph== | ==Micrograph== | ||
| Line 17: | Line 50: | ||
***Microabscesses often described as "stellate" (star-shaped). | ***Microabscesses often described as "stellate" (star-shaped). | ||
*+/-Multinucleated giant cells. | *+/-Multinucleated giant cells. | ||
*Microorganism consistent with ''B. henselae''. | |||
Notes: | Notes: | ||
| Line 38: | Line 72: | ||
==Stains== | ==Stains== | ||
*Warthin-Starry stain +ve. | *[[Warthin-Starry stain]] +ve -- bacilli. | ||
*[[Gram stain]] -ve. | |||
==IHC== | ==IHC== | ||
*B. henselae IHC stain +ve - '''diagnostic'''. | *B. henselae IHC stain +ve -- bacilli - '''diagnostic'''. | ||
==See also== | ==See also== | ||