Difference between revisions of "Parachordoma"
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==General== | ==General== | ||
*Super rare - only approximately 30 cases reported.<ref name=pmid10478665/> | *Super rare - only approximately 30 cases reported.<ref name=pmid10478665/> | ||
*Slow growing.<ref name=pmid10809219/> | |||
==Gross== | |||
Features:<ref name=pmid10809219/> | |||
*Deep soft tissue lesion. | |||
*Firm. | |||
*Well-circumscribed. | |||
*Most often thigh or arm.<ref name=pmid10478665/> | |||
==Microscopic== | ==Microscopic== | ||
Latest revision as of 03:30, 30 December 2013
Parachordoma is a very rare paraspinal tumour that is similar to chordoma.[1]
General
Gross
Features:[1]
- Deep soft tissue lesion.
- Firm.
- Well-circumscribed.
- Most often thigh or arm.[2]
Microscopic
Features:[2]
- Multivacuolated cells (physaliferous cell-like) - key feature.
- May be rare.
- "Large" rounded eosinophilic cells - important.
- Variable matrix:
- Myxoid.
- Dense appearing hyaline - cartilage-like.
- Small cells (spindled and rounded) - common.
DDx:
Stains
- Alcian blue +ve (matrix).[2]
IHC
Features:[2]
- CK 8/18 +ve.
- EMA +ve.
- S-100 +ve.
- Vimentin +ve.
Note:
- Other keratins negative.
See also
References
- ↑ 1.0 1.1 1.2 Fisher C (May 2000). "Parachordoma exists--but what is it?". Adv Anat Pathol 7 (3): 141–8. PMID 10809219.
- ↑ 2.0 2.1 2.2 2.3 2.4 Folpe, AL.; Agoff, SN.; Willis, J.; Weiss, SW. (Sep 1999). "Parachordoma is immunohistochemically and cytogenetically distinct from axial chordoma and extraskeletal myxoid chondrosarcoma.". Am J Surg Pathol 23 (9): 1059-67. PMID 10478665.