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Difference between revisions of "Parachordoma"
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'''Parachordoma''' is a very rare paraspinal tumour that is similar to [[chordoma]].<ref name=pmid10809219>{{cite journal |author=Fisher C |title=Parachordoma exists--but what is it? |journal=Adv Anat Pathol |volume=7 |issue=3 |pages=141–8 |year=2000 |month=May |pmid=10809219 |doi= |url=}}</ref> | '''Parachordoma''' is a very rare paraspinal tumour that is similar to [[chordoma]].<ref name=pmid10809219>{{cite journal |author=Fisher C |title=Parachordoma exists--but what is it? |journal=Adv Anat Pathol |volume=7 |issue=3 |pages=141–8 |year=2000 |month=May |pmid=10809219 |doi= |url=}}</ref> | ||
==General== | |||
*Super rare - only approximately 30 cases reported.<ref name=pmid10478665/> | |||
==Microscopic== | |||
Features:<ref name=pmid10478665/> | |||
*Multivacuolated cells (physaliferous cell-like) - '''key feature'''. | |||
**May be rare. | |||
*"Large" rounded eosinophilic cells - '''important'''. | |||
*Variable matrix: | |||
**Myxoid. | |||
**Dense appearing hyaline - [[cartilage]]-like. | |||
*Small cells (spindled and rounded) - common. | |||
DDx: | |||
*[[Chordoma]]. | |||
*[[Extraskeletal myxoid chondrosarcoma]]. | |||
==Stains== | |||
*Alcian blue +ve (matrix).<ref name=pmid10478665/> | |||
==IHC== | ==IHC== | ||
<ref name=pmid10478665>{{Cite journal | last1 = Folpe| first1 = AL.| last2 = Agoff| first2 = SN.| last3 = Willis| first3 = J.| last4 = Weiss| first4 = SW.| title = Parachordoma is immunohistochemically and cytogenetically distinct from axial chordoma and extraskeletal myxoid chondrosarcoma.| journal = Am J Surg Pathol| volume = 23| issue = 9| pages = 1059-67| month = Sep| year = 1999| doi = | PMID = 10478665 }}</ref> | Features:<ref name=pmid10478665>{{Cite journal | last1 = Folpe| first1 = AL.| last2 = Agoff| first2 = SN.| last3 = Willis| first3 = J.| last4 = Weiss| first4 = SW.| title = Parachordoma is immunohistochemically and cytogenetically distinct from axial chordoma and extraskeletal myxoid chondrosarcoma.| journal = Am J Surg Pathol| volume = 23| issue = 9| pages = 1059-67| month = Sep| year = 1999| doi = | PMID = 10478665 }}</ref> | ||
*CK 8/18 +ve. | |||
*EMA +ve. | |||
*S-100 +ve. | |||
*Vimentin +ve. | |||
Note: | |||
*Other keratins negative. | |||
==See also== | |||
*[[Chordoma]]. | |||
==References== | ==References== | ||