Difference between revisions of "Mantle cell lymphoma"

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#redirect [[small cell lymphomas#Mantle cell lymphoma]]
'''Mantle cell lymphoma''', abbreviated '''MCL''', is less common [[small cell lymphoma]] that is relatively aggressive when compared to other small cell lymphomas.
 
==General==
*Relatively aggressive - guarded prognosis.<ref name=pmid10583923>{{Cite journal  | last1 = Hankin | first1 = RC. | last2 = Hunter | first2 = SV. | title = Mantle cell lymphoma. | journal = Arch Pathol Lab Med | volume = 123 | issue = 12 | pages = 1182-8 | month = Dec | year = 1999 | doi = 10.1043/0003-9985(1999)1231182:MCL2.0.CO;2 | PMID = 10583923 }}</ref>
 
==Microscopic==
Features:<ref>Good, D. 17 August 2010.</ref>
*Small monomorphic (uniform size, shape and staining) lymphoid population.
*Abundant mitoses.
*Scattered epithelioid histiocytes (should not be confused with tingible-body macrophages).
*Sclerosed blood vessels.
 
DDx:
*Other small cell lymphomas, esp. marginal zone lymphoma.
*[[Burkitt's lymphoma]].
 
===Images===
<gallery>
Image:Mantle cell lymphoma - low mag.jpg | MCL - low mag. (WC)
Image:Mantle cell lymphoma - intermed mag.jpg | MCL - intermed. mag. (WC)
Image:Mantle cell lymphoma - low mag - cyclin D1.jpg | MCL - low mag. - cyclin D1. (WC)
Image:Mantle cell lymphoma - intermed mag - cyclin D1.jpg | MCL - intermed. mag. - cyclin D1. (WC)
</gallery>
www:
*[http://path.upmc.edu/cases/case441.html MCL - several images (upmc.edu)].
 
==IHC==
*CD5 +ve.
**Negative in case reports.<ref>URL: [http://path.upmc.edu/cases/case308/dx.html http://path.upmc.edu/cases/case308/dx.html]. Accessed on: 14 January 2012.</ref>
*CD43 +ve.
*Cyclin D1 +ve.
**[[AKA]] BCL1, AKA CCND1.<ref name=omim168461>{{OMIM|168461}}</ref>
 
Others:
*CD23 -ve.
**Positive in CLL.
 
==Molecular==
*t(11;14)(q13;q32) / IGH-CCND1.<ref>URL: [http://atlasgeneticsoncology.org/Anomalies/t1114ID2021.html http://atlasgeneticsoncology.org/Anomalies/t1114ID2021.html]. Accessed on: 10 August 2010.</ref>
 
==See also==
*[[Small cell lymphomas]].
 
==References==
{{Reflist|2}}


[[Category:Diagnosis]]
[[Category:Diagnosis]]
[[Category:Small cell lymphomas]]

Revision as of 02:16, 30 December 2013

Mantle cell lymphoma, abbreviated MCL, is less common small cell lymphoma that is relatively aggressive when compared to other small cell lymphomas.

General

  • Relatively aggressive - guarded prognosis.[1]

Microscopic

Features:[2]

  • Small monomorphic (uniform size, shape and staining) lymphoid population.
  • Abundant mitoses.
  • Scattered epithelioid histiocytes (should not be confused with tingible-body macrophages).
  • Sclerosed blood vessels.

DDx:

Images

  • MCL - low mag. (WC)

  • MCL - intermed. mag. (WC)

  • MCL - low mag. - cyclin D1. (WC)

  • MCL - intermed. mag. - cyclin D1. (WC)

www:

IHC

  • CD5 +ve.
    • Negative in case reports.[3]
  • CD43 +ve.
  • Cyclin D1 +ve.

Others:

  • CD23 -ve.
    • Positive in CLL.

Molecular

  • t(11;14)(q13;q32) / IGH-CCND1.[5]

See also

References

  1. ↑ Hankin, RC.; Hunter, SV. (Dec 1999). "Mantle cell lymphoma.". Arch Pathol Lab Med 123 (12): 1182-8. doi:10.1043/0003-9985(1999)1231182:MCL2.0.CO;2. PMID 10583923.
  2. ↑ Good, D. 17 August 2010.
  3. ↑ URL: http://path.upmc.edu/cases/case308/dx.html. Accessed on: 14 January 2012.
  4. ↑ Online 'Mendelian Inheritance in Man' (OMIM) 168461
  5. ↑ URL: http://atlasgeneticsoncology.org/Anomalies/t1114ID2021.html. Accessed on: 10 August 2010.
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