Difference between revisions of "Neuropathology"

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Neuropathology (view source)

Revision as of 18:45, 11 November 2010

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Image: [http://www.pathconsultddx.com/pathCon/largeImage?pii=S1559-8675(06)70787-2&figureId=fig1 Cerebral abscess (pathconsultddx.com)].
Image: [http://www.pathconsultddx.com/pathCon/largeImage?pii=S1559-8675(06)70787-2&figureId=fig1 Cerebral abscess (pathconsultddx.com)].


==Dementia==
==Neurodegenerative diseases==
*Alzheimer's dementia.
{{Main|Neurodegenerative diseases}}
*Vascular.
This is a hueueuge topic.  It is covered its own article and includes a general discussion of dementia.
**multi-infarct dementia.
*Parkinson's associated dementia.
*Lewy body dementia.
*Alcohol-related dementia.
*Fronto-temporal dementia (Pick disease).
*Multisystem atrophy.
 
Mnemonic ''VITAMIN D VEST'':<ref>TN06 PS19</ref>
*Vitamin deficiency (B12, folate, thiamine).
*Infection (HIV).
*Trauma.
*Anoxia.
*Metabolic (Diabetes).
*Intracranial tumour.
*Normal pressure hydrocephalus.
*Degenerative (Alzheimer's, Huntington's, CJD).
*Vascular.
*Endocrine.
*Space occupying lesion (chronic subdural hematoma).
*Toxins (alcohol).
 
===Lewy body dementia===
*Parkinsonian features.
*Hallucinations (visual).
*Progressive cog. decline with fluctuations.
 
===Multiple system atrophy===
*Alpha-synuclein-rich glial cytoplasmic inclusions - finding at autopsy.<ref name=pmid18825660>{{Cite journal  | last1 = Wenning | first1 = GK. | last2 = Stefanova | first2 = N. | last3 = Jellinger | first3 = KA. | last4 = Poewe | first4 = W. | last5 = Schlossmacher | first5 = MG. | title = Multiple system atrophy: a primary oligodendrogliopathy. | journal = Ann Neurol | volume = 64 | issue = 3 | pages = 239-46 | month = Sep | year = 2008 | doi = 10.1002/ana.21465 | PMID = 18825660 }}
</ref>
**Alpha-synuclein is implicated in a number of neurodegenerative diseases.<ref name=pmid18855701>{{Cite journal | last1 = Uversky | first1 = VN. | title = Alpha-synuclein misfolding and neurodegenerative diseases. | journal = Curr Protein Pept Sci | volume = 9 | issue = 5 | pages = 507-40 | month = Oct | year = 2008 | doi =  | PMID = 18855701 }}</ref>
 
===Huntington disease===
====General====
*Autosomal dominant inheritance.
*Mutation: unstable CAG repeat.<ref name=pmid20360611>{{cite journal |author=Kumar P, Kalonia H, Kumar A |title=Huntington's disease: pathogenesis to animal models |journal=Pharmacol Rep |volume=62 |issue=1 |pages=1–14 |year=2010 |pmid=20360611 |doi= |url=}}</ref>
====Gross====
*Missing caudate.<ref>URL: [http://moon.ouhsc.edu/kfung/jty1/NeuroTest/Q07-Ans.htm http://moon.ouhsc.edu/kfung/jty1/NeuroTest/Q07-Ans.htm]. Accessed on: 29 October 2010.</ref>
 
Image: [http://moon.ouhsc.edu/kfung/jty1/NeuroTest/Q07-Ans.htm Huntington's disease (ouhsc.edu)].


==Cysts==
==Cysts==
Michael
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