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Difference between revisions of "Gastrointestinal stromal tumour"
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Gastrointestinal stromal tumour (view source)
Revision as of 15:39, 13 December 2013
, 15:39, 13 December 2013no edit summary
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| LMDDx = [[schwannoma]], [[leiomyoma]], [[leiomyosarcoma]], [[neurofibroma]], [[desmoid-type fibromatosis]] | | LMDDx = [[schwannoma]], [[leiomyoma]], [[leiomyosarcoma]], [[neurofibroma]], [[desmoid-type fibromatosis]] | ||
| Stains = | | Stains = | ||
| IHC = | | IHC = CD117 +ve, DOG-1 +ve, CD34 +ve, S-100 -ve | ||
| EM = | | EM = | ||
| Molecular = mutation in KIT gene ''or'' PDGFRA gene | | Molecular = mutation in KIT gene ''or'' PDGFRA gene | ||
| Line 111: | Line 111: | ||
==IHC== | ==IHC== | ||
*CD117 +ve in 95%.<ref name=pmid17090188/> | *CD117 +ve in 95%.<ref name=pmid17090188/> | ||
**[[Mast cell]]s are the internal positive control. | **[[Mast cell]]s are the internal positive control. | ||
*DOG1 +ve.<ref name=pmid19011564>{{Cite journal | last1 = Liegl | first1 = B. | last2 = Hornick | first2 = JL. | last3 = Corless | first3 = CL. | last4 = Fletcher | first4 = CD. | title = Monoclonal antibody DOG1.1 shows higher sensitivity than KIT in the diagnosis of gastrointestinal stromal tumors, including unusual subtypes. | journal = Am J Surg Pathol | volume = 33 | issue = 3 | pages = 437-46 | month = Mar | year = 2009 | doi = 10.1097/PAS.0b013e318186b158 | PMID = 19011564 }}</ref> | |||
**More sensitive than CD117. | |||
Others: | |||
*CD34 +ve in 70%.<ref name=pmid17090188/> | |||
*Desmin +ve in 5%.<ref name=pmid17090188/> | *Desmin +ve in 5%.<ref name=pmid17090188/> | ||
===IHC work-up panel=== | ===IHC work-up panel=== | ||