Difference between revisions of "Hemolytic uremic syndrome"
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**Verotoxins from ''E. coli'' O157:H7 --> endothelial injury.<ref name=pmid19180125>{{cite journal |author=Petruzziello TN, Mawji IA, Khan M, Marsden PA |title=Verotoxin biology: molecular events in vascular endothelial injury |journal=Kidney Int. Suppl. |volume= |issue=112 |pages=S17–9 |year=2009 |month=February |pmid=19180125 |doi=10.1038/ki.2008.612 |url=}}</ref> | **Verotoxins from ''E. coli'' O157:H7 --> endothelial injury.<ref name=pmid19180125>{{cite journal |author=Petruzziello TN, Mawji IA, Khan M, Marsden PA |title=Verotoxin biology: molecular events in vascular endothelial injury |journal=Kidney Int. Suppl. |volume= |issue=112 |pages=S17–9 |year=2009 |month=February |pmid=19180125 |doi=10.1038/ki.2008.612 |url=}}</ref> | ||
==Relation to thrombotic thrombocytopenic purpura (TTP)== | ==Relation to [[thrombotic thrombocytopenic purpura]] (TTP)== | ||
*TTP is the main (clinical) DDx of HUS. | *TTP is the main (clinical) DDx of HUS. | ||
**It is classically characterized by: microangiopathic hemolytic anemia, thrombocytopenia, fever, mild renal failure, and prominent neurologic symptoms. | **It is classically characterized by: microangiopathic hemolytic anemia, thrombocytopenia, fever, mild renal failure, and prominent neurologic symptoms. | ||
Revision as of 04:29, 9 November 2010
Hemolytic uremic syndrome, abbreviated HUS, is the triad of:[1]
- Microangiopathic hemolytic anemia.
- Microangiopathic = disease affecting small blood vessels.[2]
- Thrombocytopenia = low platelet count.
- Acute renal failure.
Etiology
- Rare (uncooked) hamburger.
- E. coli serotype O157:H7.
- Verotoxins from E. coli O157:H7 --> endothelial injury.[3]
Relation to thrombotic thrombocytopenic purpura (TTP)
- TTP is the main (clinical) DDx of HUS.
- It is classically characterized by: microangiopathic hemolytic anemia, thrombocytopenia, fever, mild renal failure, and prominent neurologic symptoms.
- Both are classified as thrombotic microangiopathies.[4]
See also
References
- ↑ URL: http://emedicine.medscape.com/article/779218-overview. Accessed on: 8 September 2010.
- ↑ URL: http://www.mercksource.com/pp/us/cns/cns_hl_dorlands_split.jsp?pg=/ppdocs/us/common/dorlands/dorland/one/000005089.htm. Accessed on: 9 September 2010.
- ↑ Petruzziello TN, Mawji IA, Khan M, Marsden PA (February 2009). "Verotoxin biology: molecular events in vascular endothelial injury". Kidney Int. Suppl. (112): S17–9. doi:10.1038/ki.2008.612. PMID 19180125.
- ↑ URL: http://emedicine.medscape.com/article/779218-overview. Accessed on: 8 September 2010.