Difference between revisions of "Carcinoma ex pleomorphic adenoma"

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==General==
==General==
Definition:  
Definition:  
*Malignancy arising in a ''[[pleomorphic adenoma]]''.<ref name=pmid21744105>{{Cite journal  | last1 = Antony | first1 = J. | last2 = Gopalan | first2 = V. | last3 = Smith | first3 = RA. | last4 = Lam | first4 = AK. | title = Carcinoma ex pleomorphic adenoma: a comprehensive review of clinical, pathological and molecular data. | journal = Head Neck Pathol | volume = 6 | issue = 1 | pages = 1-9 | month = Mar | year = 2012 | doi = 10.1007/s12105-011-0281-z | PMID = 21744105 }}</ref>
*Malignancy arising from a ''[[pleomorphic adenoma]]''.<ref name=pmid21744105>{{Cite journal  | last1 = Antony | first1 = J. | last2 = Gopalan | first2 = V. | last3 = Smith | first3 = RA. | last4 = Lam | first4 = AK. | title = Carcinoma ex pleomorphic adenoma: a comprehensive review of clinical, pathological and molecular data. | journal = Head Neck Pathol | volume = 6 | issue = 1 | pages = 1-9 | month = Mar | year = 2012 | doi = 10.1007/s12105-011-0281-z | PMID = 21744105 }}</ref>


Diagnosis (either 1 or 2):  
Diagnosis (either 1 or 2):  

Revision as of 17:15, 23 November 2013

Carcinoma ex pleomorphic adenoma, abbreviated ca ex PA, is a rare malignant salivary gland tumour that arise from a pleomorphic adenoma.

General

Definition:

Diagnosis (either 1 or 2):

  1. History of a pleomorphic adenoma at the same site.
  2. Features of a pleomorphic adenoma and a carcinoma.

Epidemiology:

  • Rare.

Gross

  • Usually mass lesion - partoid gland.[1]

Microscopic

Features:

  • Cells with cytologic features of malignancy - key feature.
  • Architecture (any of the following):
    • Glands.
    • Nests.
    • Single cells (may be subtle).

Architectural patterns:

Note:

  • Often adenocarcinoma-like.
  • Myoepithelial cells may be clear cells.

DDx:

Subclassification

Extent of invasion:[2]

  1. Non-invasive AKA intracapsular AKA in situ.
  2. Minimally invasive <=1.5 mm beyond the capsule.
  3. Widely invasive >1.5 mm beyond the capsule.

See also

References

  1. ↑ 1.0 1.1 Antony, J.; Gopalan, V.; Smith, RA.; Lam, AK. (Mar 2012). "Carcinoma ex pleomorphic adenoma: a comprehensive review of clinical, pathological and molecular data.". Head Neck Pathol 6 (1): 1-9. doi:10.1007/s12105-011-0281-z. PMID 21744105.
  2. ↑ URL: http://www.cap.org/apps/docs/committees/cancer/cancer_protocols/2011/MajorSalGlands_11protocol.pdf. Accessed on: 2 April 2012.
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