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Difference between revisions of "Gestational trophoblastic disease"
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Gestational trophoblastic disease (view source)
Revision as of 20:21, 20 November 2013
, 20:21, 20 November 2013→Microscopic
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! [[Blood vessel]]s | ! [[Blood vessel]]s | ||
! Nucleated RBCs | ! Nucleated RBCs | ||
! p57 / Ki-67<ref>URL: [http://www.ihcworld.com/_newsletter/2003/focus_mar_2003.pdf http://www.ihcworld.com/_newsletter/2003/focus_mar_2003.pdf]. Accessed on: 28 May 2011.</ref> staining | ! p57 / Ki-67 ‡<ref>URL: [http://www.ihcworld.com/_newsletter/2003/focus_mar_2003.pdf http://www.ihcworld.com/_newsletter/2003/focus_mar_2003.pdf]. Accessed on: 28 May 2011.</ref> staining | ||
! Ploidy | ! Ploidy | ||
! Micrograph | ! Micrograph | ||
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| [http://www.ipath-network.com/ipath/object/view/181344] | | [http://www.ipath-network.com/ipath/object/view/181344] | ||
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Note: | |||
* ‡ The amount of Ki-67 staining varies considerably based on what one reads. Chen ''at al.''<ref>{{Cite journal | last1 = Chen | first1 = Y. | last2 = Shen | first2 = D. | last3 = Gu | first3 = Y. | last4 = Zhong | first4 = P. | last5 = Xie | first5 = J. | last6 = Song | first6 = Q. | title = The diagnostic value of Ki-67, P53 and P63 in distinguishing partial Hydatidiform mole from hydropic abortion. | journal = Wien Klin Wochenschr | volume = 124 | issue = 5-6 | pages = 184-7 | month = Mar | year = 2012 | doi = 10.1007/s00508-011-0119-4 | PMID = 22218717 }}</ref> suggest 25% versus 5% for partial mole versus hydropic abortus. | |||
====Mole | ====Mole versus normal==== | ||
*Moles have large [[chorionic villi]] with edema and abnormal blood vessels.<ref>URL: [http://pathologyoutlines.com/placenta.html#hydatgeneral http://pathologyoutlines.com/placenta.html#hydatgeneral].</ref> | *Moles have large [[chorionic villi]] with edema and abnormal blood vessels.<ref>URL: [http://pathologyoutlines.com/placenta.html#hydatgeneral http://pathologyoutlines.com/placenta.html#hydatgeneral].</ref> | ||
====Non-molar | ====Non-molar versus partial versus complete - short version==== | ||
Features:<ref>{{Cite journal | last1 = Howat | first1 = AJ. | last2 = Beck | first2 = S. | last3 = Fox | first3 = H. | last4 = Harris | first4 = SC. | last5 = Hill | first5 = AS. | last6 = Nicholson | first6 = CM. | last7 = Williams | first7 = RA. | title = Can histopathologists reliably diagnose molar pregnancy? | journal = J Clin Pathol | volume = 46 | issue = 7 | pages = 599-602 | month = Jul | year = 1993 | doi = | PMID = 8157742 }}</ref> | Features:<ref>{{Cite journal | last1 = Howat | first1 = AJ. | last2 = Beck | first2 = S. | last3 = Fox | first3 = H. | last4 = Harris | first4 = SC. | last5 = Hill | first5 = AS. | last6 = Nicholson | first6 = CM. | last7 = Williams | first7 = RA. | title = Can histopathologists reliably diagnose molar pregnancy? | journal = J Clin Pathol | volume = 46 | issue = 7 | pages = 599-602 | month = Jul | year = 1993 | doi = | PMID = 8157742 }}</ref> | ||
*Non-molar pregnancy: polar proliferation of trophoblastic tissue. | *Non-molar pregnancy: polar proliferation of trophoblastic tissue. | ||