Difference between revisions of "Leydig cell tumour"
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'''Leydig cell tumour''', also known as '''interstitial cell tumour''', is an uncommon benign sex cord-stromal tumour, typically seen in the [[testis]]. | |||
==General== | |||
*Arises from the interstitial cell. | |||
*May be associated with increased testosterone. | |||
==Gross== | |||
*Solid, lobulated. | |||
*Red/tan. | |||
Image: | |||
*[http://www.flickr.com/photos/35441329@N05/5056465301/sizes/m/in/photostream/ Leydig cell tumour (flickr.com)]. | |||
==Microscopic== | |||
Features:<ref name=Ref_GUP581>{{Ref GUP|581}}</ref> | |||
*Vacuolization (cytoplasm) - '''key feature'''. | |||
*Cytoplasm - clear to eosinophilic - '''important'''. | |||
*''Reinke crystals'' - classic finding, usually not present. | |||
**Cylindrical crystalloid eosinophilic cytoplasmic bodies. | |||
*Nucleoli common. | |||
*Round nuclei. | |||
DDx: | |||
*[[Spermatocytic seminoma]] - may have eosinophilic cytoplasm. | |||
*[[Pregnancy luteoma]] - occurs during pregnancy, as the name implies. | |||
===Images=== | |||
<gallery> | |||
Image:Leydig_cell_tumour1.jpg |Leydig cell tumour - low mag. (WC) | |||
Image:Leydig_cell_tumour2.jpg |Leydig cell tumour - intermed. mag. (WC) | |||
Image:Leydig_cell_tumour3.jpg |Leydig cell tumour - high mag. (WC) | |||
</gallery> | |||
www: | |||
*[http://path.upmc.edu/cases/case404.html Leydig cell tumour - several images (upmc.edu)]. | |||
==IHC== | |||
*Inhibin-alpha. | |||
*Calretinin.<ref>URL: [http://www.antibodybeyond.com/reviews/cell-markers/leydig-cell-marker.htm http://www.antibodybeyond.com/reviews/cell-markers/leydig-cell-marker.htm]. Accessed on: 18 May 2010.</ref><ref name=pmid15950053>{{cite journal |author=Bar-Shira Maymon B, Yavetz H, Yogev L, ''et al.'' |title=Detection of calretinin expression in abnormal immature Sertoli cells in non-obstructive azoospermia |journal=Acta Histochem. |volume=107 |issue=2 |pages=105–12 |year=2005 |pmid=15950053 |doi=10.1016/j.acthis.2005.02.002 |url=}}</ref> | |||
*Melan A.<ref name=pmid12966351>{{cite journal |author=Yao DX, Soslow RA, Hedvat CV, Leitao M, Baergen RN |title=Melan-A (A103) and inhibin expression in ovarian neoplasms |journal=Appl. Immunohistochem. Mol. Morphol. |volume=11 |issue=3 |pages=244–9 |year=2003 |month=September |pmid=12966351 |doi= |url=}}</ref> | |||
**AKA ''MART-1''. | |||
**Expressed in [[melanoma]], [[adrenal gland|adrenal tissue]], steroid-secreting tumours. | |||
==See also== | |||
*[[Testis]]. | |||
*[[Sertoli-Leydig tumour]]. | |||
==References== | |||
{{Reflist|2}} | |||
[[Category:Testis]] | |||
[[Category:Diagnosis]] | [[Category:Diagnosis]] | ||
Revision as of 04:02, 18 November 2013
Leydig cell tumour, also known as interstitial cell tumour, is an uncommon benign sex cord-stromal tumour, typically seen in the testis.
General
- Arises from the interstitial cell.
- May be associated with increased testosterone.
Gross
- Solid, lobulated.
- Red/tan.
Image:
Microscopic
Features:[1]
- Vacuolization (cytoplasm) - key feature.
- Cytoplasm - clear to eosinophilic - important.
- Reinke crystals - classic finding, usually not present.
- Cylindrical crystalloid eosinophilic cytoplasmic bodies.
- Nucleoli common.
- Round nuclei.
DDx:
- Spermatocytic seminoma - may have eosinophilic cytoplasm.
- Pregnancy luteoma - occurs during pregnancy, as the name implies.
Images
Leydig cell tumour - low mag. (WC)
Leydig cell tumour - intermed. mag. (WC)
Leydig cell tumour - high mag. (WC)
www:
IHC
- Inhibin-alpha.
- Calretinin.[2][3]
- Melan A.[4]
- AKA MART-1.
- Expressed in melanoma, adrenal tissue, steroid-secreting tumours.
See also
References
- ↑ Zhou, Ming; Magi-Galluzzi, Cristina (2006). Genitourinary Pathology: A Volume in Foundations in Diagnostic Pathology Series (1st ed.). Churchill Livingstone. pp. 581. ISBN 978-0443066771.
- ↑ URL: http://www.antibodybeyond.com/reviews/cell-markers/leydig-cell-marker.htm. Accessed on: 18 May 2010.
- ↑ Bar-Shira Maymon B, Yavetz H, Yogev L, et al. (2005). "Detection of calretinin expression in abnormal immature Sertoli cells in non-obstructive azoospermia". Acta Histochem. 107 (2): 105–12. doi:10.1016/j.acthis.2005.02.002. PMID 15950053.
- ↑ Yao DX, Soslow RA, Hedvat CV, Leitao M, Baergen RN (September 2003). "Melan-A (A103) and inhibin expression in ovarian neoplasms". Appl. Immunohistochem. Mol. Morphol. 11 (3): 244–9. PMID 12966351.