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Endometrial stromal sarcoma (view source)
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'''Endometrial stromal sarcoma''', abbreviated '''ESS''', is a rare malignant mesenchymal [[uterine tumours|tumour of the uterus]]. | |||
It is also known as '''low-grade endometrial stromal sarcoma''' | |||
==General== | |||
*Rare.<ref name=pmid20179433> {{Cite journal | last1 = Chew | first1 = I. | last2 = Oliva | first2 = E. | title = Endometrial stromal sarcomas: a review of potential prognostic factors. | journal = Adv Anat Pathol | volume = 17 | issue = 2 | pages = 113-21 | month = Mar | year = 2010 | doi = 10.1097/PAP.0b013e3181cfb7c2 | PMID = 20179433 }}</ref> | |||
==Microscopic== | |||
Features: | |||
*Highly cellular Islands with a wavy irregular border. | |||
**Border has finger-like projections/[[tongue]]-like projections. | |||
**Benign uterine smooth muscle between islands of tumour cells. | |||
*Epithelioid cells. | |||
*High [[NC ratio]]. | |||
*Thin blood vessels within islands of cells. | |||
**Tumour cells pallisade around the vessels. | |||
Notes: | |||
*Vaguely resembles the stroma of proliferative endometrium. | |||
DDx: | |||
*[[Leiomyoma]]. | |||
*[[Endometrial stromal nodule]]. | |||
*[[Uterine leiomyosarcoma]]. | |||
===Images=== | |||
*[http://commons.wikimedia.org/wiki/File:EndometrialStromalSarcoma.JPG ESS (WC)]. | |||
*[http://commons.wikimedia.org/wiki/File:EndometrialStromalSarcomaLowGrade.JPG Endometrial stromal sarcoma - low grade (WC)]. | |||
*[http://jcp.bmj.com/content/60/3/235/F5.large.jpg ESS in an article with many crappy images].<ref name=pmid17347285>{{Cite journal | last1 = Baker | first1 = P. | last2 = Oliva | first2 = E. | title = Endometrial stromal tumours of the uterus: a practical approach using conventional morphology and ancillary techniques. | journal = J Clin Pathol | volume = 60 | issue = 3 | pages = 235-43 | month = Mar | year = 2007 | doi = 10.1136/jcp.2005.031203 | PMID = 17347285 | url = http://jcp.bmj.com/content/60/3/235.full }}</ref> | |||
*[http://radiographics.rsna.org/content/25/1/21/F42.expansion.html ESS (rsna.org)]. | |||
==IHC== | |||
Features:<ref name=pmid14751141>{{Cite journal | last1 = Zhu | first1 = XQ. | last2 = Shi | first2 = YF. | last3 = Cheng | first3 = XD. | last4 = Zhao | first4 = CL. | last5 = Wu | first5 = YZ. | title = Immunohistochemical markers in differential diagnosis of endometrial stromal sarcoma and cellular leiomyoma. | journal = Gynecol Oncol | volume = 92 | issue = 1 | pages = 71-9 | month = Jan | year = 2004 | doi = | PMID = 14751141 }}</ref> | |||
*CD10 +ve. | |||
*h-caldesmin -ve. | |||
**[[Leiomyoma]]s +ve. | |||
*PR +/-ve. | |||
*ER +/-ve. | |||
==Molecular== | |||
May be associated a recurrent [[translocation]]:<ref name=pmid12648605>{{Cite journal | last1 = Amant | first1 = F. | last2 = Moerman | first2 = P. | last3 = Cadron | first3 = I. | last4 = Hagemeijer | first4 = A. | last5 = Vergote | first5 = I. | last6 = Debiec-Rychter | first6 = M. | title = Endometrial stromal sarcoma with a sole t(X;17) chromosome change: report of a case and review of the literature. | journal = Gynecol Oncol | volume = 88 | issue = 3 | pages = 459-62 | month = Mar | year = 2003 | doi = | PMID = 12648605 | URL = http://www.sciencedirect.com/science/article/pii/S0090825802000963 }}</ref> | |||
*t(7;17)(p15;q21). | |||
**JAZF1 - chromosome 7.<ref name=omim606246>{{OMIM|606246}}</ref> | |||
**SUZ12 - chromosome 17.<ref name=omim606245>{{OMIM|606245}}</ref> | |||
==See also== | |||
*[[Uterine tumours]]. | |||
==References== | |||
{{Reflist|2}} | |||
[[Category:Gynecologic pathology]] | |||
[[Category:Diagnosis]] | [[Category:Diagnosis]] | ||