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m (→Astrocytomas) |
(→Meningioma: fix classification) |
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**Low mitotic rate. | **Low mitotic rate. | ||
*Grade 2: | *Grade 2: | ||
**Intermediate mitotic rate (>= 4 mitoses/HPF - for whatever ''HPF'' means, see [[HPFitis]].) | **Brain-invasive meningioma. | ||
**Three of the following five features: | ***Protrusion of meningioma into brain. | ||
**#Sheeting architecture. | ****Meninogioma with entraped GFAP +ve tissue. | ||
**#High NC ratio; clusters of "lymphocyte-like" cells. | **Atypical meningioma. | ||
**#Hypercellularity. | ***Intermediate mitotic rate (>= 4 mitoses/10 HPF - for whatever ''HPF'' means, see [[HPFitis]].) | ||
**#Macronucleoli. | ***Three of the following five features: | ||
**#Necrosis not caused by treatment, e.g. radiation or embolization. | ***#Sheeting architecture. | ||
***#High NC ratio; clusters of "lymphocyte-like" cells. | |||
***#Hypercellularity. | |||
***#Macronucleoli. | |||
***#Necrosis not caused by treatment, e.g. radiation or embolization. | |||
*Grade 3: | *Grade 3: | ||
**High mitotic rate (>=20 mitoses/HPF - for whatever ''HPF'' means, see [[HPFitis]].) | **High mitotic rate (>=20 mitoses/10 HPF - for whatever ''HPF'' means, see [[HPFitis]].) | ||
**"Frank anaplasia"; marked nuclear atypia. | **"Frank anaplasia"; marked nuclear atypia. | ||
edits