Difference between revisions of "Neuropathology tumours"

Jump to navigation Jump to search

Neuropathology tumours (view source)

Revision as of 15:43, 1 October 2013

2,348 bytes removed ,  15:43, 1 October 2013
→‎Chordoma: split-out
(→‎Images: +image)
(→‎Chordoma: split-out)
Line 847: Line 847:


==Chordoma==
==Chordoma==
===General===
{{Main|Chordoma}}
*Location: usually sacrum or clivus.
*It is a [[bone tumour]].
 
===Gross===
*Soft, gelatinous, lobulated.<ref>URL: [http://www.histopathology-india.net/Chordoma.htm http://www.histopathology-india.net/Chordoma.htm]. Accessed on: 12 April 2012.</ref>
 
DDx:
*Bony [[metastasis]] (mucinous carcinoma) - typically multifocal.
 
Image:
*[http://www.flickr.com/photos/bc_the_path/4428268879/in/photostream/ Chordoma (flickr.com)].
 
===Microscopic===
Features:<ref name=Ref_DCHH184>{{Ref DCHH|184}}</ref>
*Architecture: islands of cells surrounded by fibrous tissue.
**Also described as "lobulated" architecture; may not be apparent.
*[[Myxoid]] background - grey extracellular material, variable amount present.
*Mixed cell population:
*#Abundant eosinophilic cytoplasm.
*#''Physaliphorous cells'' or ''bubble cells'' - '''key feature'''.
*#*Have a very large clear bubble with a sharp border; bubble does not compress nucleus - nucleus may be in bubble.
 
DDx:
*[[Chondrosarcoma]].
 
Images:
*[[WC]]:
**[http://commons.wikimedia.org/wiki/File:Chordoma_-_low_mag.jpg Chordoma - low mag. (WC)].
**[http://commons.wikimedia.org/wiki/File:Chordoma_-_high_mag.jpg Chordoma - high mag. (WC)].
*www:
**[http://path.upmc.edu/cases/case64.html Chordoma (upmc.edu)].
**[http://path.upmc.edu/cases/case312/micro.html Chordoma - sacrum - several images (upmc.edu)].
**[http://path.upmc.edu/cases/case689.html Chordoma - additional case with several images (upmc.edu)].
 
===IHC===
Features:<ref>URL: [http://path.upmc.edu/cases/case312/micro.html http://path.upmc.edu/cases/case312/micro.html]. Accessed on: 14 January 2012.</ref><ref name=pmid2431128>{{Cite journal  | last1 = Coindre | first1 = JM. | last2 = Rivel | first2 = J. | last3 = Trojani | first3 = M. | last4 = De Mascarel | first4 = I. | last5 = De Mascarel | first5 = A. | title = Immunohistological study in chordomas. | journal = J Pathol | volume = 150 | issue = 1 | pages = 61-3 | month = Sep | year = 1986 | doi = 10.1002/path.1711500110 | PMID = 2431128 }}</ref>
*S100 +ve.
*AE1/AE3 +ve.
*Brachyury +ve -- '''key stain'''.
**Protein important for axial development, affects notochord development.<ref name=omim601397>{{OMIM|601397}}</ref>
**''Brachyury'' literally means ''short tail''.<ref>URL: [http://www.jstor.org/pss/86845 http://www.jstor.org/pss/86845]. Accessed on: 18 May 2010.</ref>
*EMA +ve.


==Hemangioblastoma==
==Hemangioblastoma==
Michael
48,830

edits

Retrieved from "https://librepathology.org/wiki/Special:MobileDiff/24603"

Navigation menu