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Difference between revisions of "Fundic gland polyp"
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{{ Infobox diagnosis | |||
| Name = {{PAGENAME}} | |||
| Image = | |||
| Width = | |||
| Caption = | |||
| Micro = | |||
| Subtypes = | |||
| LMDDx = [[hyperplastic polyp of the stomach]] | |||
| Stains = | |||
| IHC = | |||
| EM = | |||
| Molecular = | |||
| IF = | |||
| Gross = | |||
| Grossing = | |||
| Site = [[stomach]] - usually fundus | |||
| Assdx = [[gastroesophageal reflux disease]] - thus PPI use | |||
| Syndromes = [[familial adenomatous polyposis]] | |||
| Clinicalhx = | |||
| Signs = | |||
| Symptoms = | |||
| Prevalence = common | |||
| Bloodwork = | |||
| Rads = | |||
| Endoscopy = polyps | |||
| Prognosis = benign | |||
| Other = | |||
| ClinDDx = [[gastric adenoma]], [[hyperplastic polyp of the stomach]] | |||
}} | |||
'''Fundic gland polyp''', abbreviated '''FGP''', is a relatively common pathology of the [[stomach]]. It is associated with [[familial adenomatous polyposis]] and proton pump inhibitor use. | |||
==General== | |||
*Most common stomach polyp.<ref name=pmid20567540/> | |||
*''Fundic'' location usually. | |||
**May be in the body.<ref name=pmid20567540>{{Cite journal | last1 = Spiegel | first1 = A. | last2 = Stein | first2 = P. | last3 = Patel | first3 = M. | last4 = Patel | first4 = R. | last5 = Lebovics | first5 = E. | title = A report of gastric fundic gland polyps. | journal = Gastroenterol Hepatol (N Y) | volume = 6 | issue = 1 | pages = 45-8 | month = Jan | year = 2010 | doi = | PMID = 20567540 }}</ref> | |||
===Clinical significance=== | |||
*Weak association with FAP ([[familial adenomatous polyposis]]).<ref name=pmid20567540/><ref name=pmid18322941>{{cite journal |author=Freeman HJ |title=Proton pump inhibitors and an emerging epidemic of gastric fundic gland polyposis |journal=World J. Gastroenterol. |volume=14 |issue=9 |pages=1318-20 |year=2008 |month=March |pmid=18322941 |doi= |url=http://www.wjgnet.com/1007-9327/14/1318.asp}}</ref> | |||
*Associated with chronic proton pump inhibitors (PPI) use -- approximately 4x risk.<ref>{{cite journal |author=Jalving M, Koornstra JJ, Wesseling J, Boezen HM, DE Jong S, Kleibeuker JH |title=Increased risk of fundic gland polyps during long-term proton pump inhibitor therapy |journal=Aliment. Pharmacol. Ther. |volume=24 |issue=9 |pages=1341-8 |year=2006 |month=November |pmid=17059515 |doi=10.1111/j.1365-2036.2006.03127.x |url=}}</ref> | |||
Notes: | |||
*Animal studies suggested PPIs cause [[neuroendocrine tumour]]s -- but this has not been found in humans.<ref>{{cite journal |author=Masaoka T, Suzuki H, Hibi T |title=Gastric epithelial cell modality and proton pump inhibitor |journal=J Clin Biochem Nutr |volume=42 |issue=3 |pages=191-6 |year=2008 |month=May |pmid=18545640 |pmc=2386521 |doi=10.3164/jcbn.2008028 |url=}}</ref> | |||
==Gross== | |||
*Polyps. | |||
Image: | |||
<gallery> | |||
Image:Endoscopic_view_of_fundic_gland_polyps.jpg | FGP on endoscopy. (WC) | |||
</gallery> | |||
==Microscopic== | |||
Features:<ref>URL: [http://moon.ouhsc.edu/kfung/jty1/opaq/PathQuiz/A2B001-PQ01-M.htm http://moon.ouhsc.edu/kfung/jty1/opaq/PathQuiz/A2B001-PQ01-M.htm]. Accessed on: 19 October 2010.</ref> | |||
*Polypoid shape (may not be appreciated on microscopy). | |||
*Dilated gastric glands. | |||
**Flatted epithelial lining (consisting of normal foveolar epithelium) - '''key feature'''. | |||
Notes: | |||
*The presence of dysplastic changes should prompt consideration of ''FAP''. | |||
DDx: | |||
*[[Hyperplastic polyp of the stomach]] - has foveolar hyperplasia, gland dilation may be present. | |||
===Images=== | |||
<gallery> | |||
Image:Fundic gland polyp (1).jpg | FGP - low mag. (WC) | |||
Image:Fundic_gland_polyp_(2).jpg | FGP - high mag. (WC) | |||
</gallery> | |||
www: | |||
*[http://moon.ouhsc.edu/kfung/jty1/opaq/PathQuiz/A2B001-PQ01-M.htm Fundic gland polyp (ouhsc.edu)]. | |||
==Sign out== | |||
<pre> | |||
POLYP, STOMACH, BIOPSY: | |||
- FUNDIC GLAND POLYP. | |||
- NEGATIVE FOR INTESTINAL METAPLASIA. | |||
- NEGATIVE FOR HELICOBACTER-LIKE ORGANISMS. | |||
- NEGATIVE FOR DYSPLASIA AND NEGATIVE FOR MALIGNANCY. | |||
</pre> | |||
==See also== | |||
*[[Stomach]]. | |||
*[[Neuroendocrine tumours]]. | |||
*[[Gastric columnar dysplasia]]. | |||
==References== | |||
{{Reflist|2}} | |||
[[Category:Stomach]] | |||
[[Category:Diagnosis]] | [[Category:Diagnosis]] | ||