Difference between revisions of "Non-malignant skin disease"

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Non-malignant skin disease (view source)

Revision as of 20:56, 12 July 2013

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→‎Lichen simplex chronicus: split out
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=Other=
=Other=
==Lichen simplex chronicus==
==Lichen simplex chronicus==
*Abbreviated ''LSC''.
{{Main|Lichen simplex chronicus}}
*[[AKA]] ''squamous cell hyperplasia''.<ref name=Ref_PBoD1011>{{Ref PBoD8|1011}}</ref>
 
===General===
*May be considered a variant of ''spongiotic dermatitis''.<ref name=Ref_DCHH296>{{Ref DCHH|296}}</ref>; more specifically, some think it is an ''atopic dermatitis'' (which fits in the large ''[[spongiotic dermatitis]]'' category).<ref name=Ref_Derm26>{{Ref Derm|26}}</ref>
*It is lumped with the [[psoriasiform dermatitides]].
 
Etiology:<ref>URL: [http://emedicine.medscape.com/article/1123423-overview http://emedicine.medscape.com/article/1123423-overview]. Accessed on: 20 August 2010.</ref>
*Pruritus (itchness) -> mechanical trauma -> lichenification (thickened/leathery<ref>URL: [http://www.medterms.com/script/main/art.asp?articlekey=10131 http://www.medterms.com/script/main/art.asp?articlekey=10131]. Accessed on: 20 August 2010.</ref>.
 
===Microscopic===
Features:<ref name=Ref_PBoD1065-6>{{Ref PBoD|1065-6}}</ref>
*Acanthosis (epithelial thickening) - irregular.
*Hyperkeratosis.
Other features:<ref>URL: [http://emedicine.medscape.com/article/1123423-diagnosis http://emedicine.medscape.com/article/1123423-diagnosis]. Accessed on: 20 August 2010.</ref>
*[[Spongiosis]] (epidermal intercellular edema -- cells appear to have a clear halo around 'em).
*[[Parakeratosis]] = retention of nuclei in the stratum corneum.
 
DDx:
*[[Prurigo nodularis]] - focal process (nodule or papule).
*Benign alveolar ridge keratosis ([[AKA]] oral lichen simplex chronicus<ref name=pmid18158926>{{Cite journal  | last1 = Natarajan | first1 = E. | last2 = Woo | first2 = SB. | title = Benign alveolar ridge keratosis (oral lichen simplex chronicus): A distinct clinicopathologic entity. | journal = J Am Acad Dermatol | volume = 58 | issue = 1 | pages = 151-7 | month = Jan | year = 2008 | doi = 10.1016/j.jaad.2007.07.011 | PMID = 18158926 }}</ref>) - see [[oral pathology]].
 
Images:
*[http://commons.wikimedia.org/w/index.php?title=File:Lichen_simplex_chronicus_-_low_mag.jpg LSC - low mag. (WC)].
*[http://commons.wikimedia.org/w/index.php?title=File:Lichen_simplex_chronicus_-_high_mag.jpg LSC - high mag. (WC)].
 
===Sign-out===
<pre>
SKIN, PUNCH BIOPSY:
- LICHEN SIMPLEX CHRONICUS.
- NEGATIVE FOR MALIGNANCY.
</pre>
 
====Oral====
<pre>
RETROMOLAR PAD, RIGHT, PUNCH BIOPSY:
- ORAL LICHEN SIMPLEX CHRONICUS.
- NEGATIVE FOR MALIGNANCY.
</pre>
 
====Micro====
The sections show a squamous mucosa with irregular psoriasiform change, parakeratosis, and focal hypergranulosis.  There is no inflammation at the interface. Epidermal intercellular bridges are easily seen.  There is no significant nuclear atypia.  Mitoses are not evident.


==Prurigo nodularis==
==Prurigo nodularis==
Michael
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