Difference between revisions of "Inflammatory fibroid polyp"
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| Caption = Inflammatory fibroid polyp. [[H&E stain]]. | | Caption = Inflammatory fibroid polyp. [[H&E stain]]. | ||
| Micro = proliferating spindle cells - loosely arranged round blood vessels with perivascular hypocellular zones, eosinophils ( | | Micro = proliferating spindle cells - loosely arranged round blood vessels with perivascular hypocellular zones, eosinophils (usually prominent), +/-leiomyoma/schwannoma-like areas - with nuclear palisading | ||
| Subtypes = | | Subtypes = | ||
| LMDDx = [[inflammatory myofibroblastic tumour]], [[GIST]], [[schwannoma]] | | LMDDx = [[inflammatory myofibroblastic tumour]], [[GIST]], [[schwannoma]] | ||
Revision as of 12:38, 12 July 2013
| Inflammatory fibroid polyp | |
|---|---|
| Diagnosis in short | |
 Inflammatory fibroid polyp. H&E stain. | |
|
| |
| LM | proliferating spindle cells - loosely arranged round blood vessels with perivascular hypocellular zones, eosinophils (usually prominent), +/-leiomyoma/schwannoma-like areas - with nuclear palisading |
| LM DDx | inflammatory myofibroblastic tumour, GIST, schwannoma |
| IHC | CD34 +ve, vimentin +ve, CD117 -ve, S-100 -ve |
| Molecular | +/-PDGFRA mutations |
| Site | stomach, other places in the GI tract |
|
| |
| Prognosis | good - benign |
Inflammatory fibroid polyp, abbreviated IFP, is an uncommon gastrointestinal polyp.
General
- Benign.
- Through-out GI tract.
- Can be thought of as granulation tissue-like.[1]
Microscopic
Features:[2]
- Proliferating spindle cells (fibroid) - key feature.
- Inflammation:
- Eosinophils - often prominent.
- +/-Leiomyoma/schwannoma-like areas - with nuclear palisading.[1]
- +/-Vascular for fibrous tissue.
- Poorly circumscribed/infiltrates into the lamina propria.
DDx:
- Inflammatory myofibroblastic tumour.
- GIST - usually sharply demarcated border.
Notes:
- Concentric = share the same centre.[4]
Images
Low mag.
Intermed. mag.
High mag.
High mag.
Very high mag.
IHC
Features:[2]
- CD34 +ve.
- There is a CD34 -ve variant.
- Vimentin +ve -- diffuse.[5]
Others:
- CD117 -ve.[6]
- S100 -ve.
Molecular
- A subset have mutations in PDGFRA.[2]
See also
References
- ↑ 1.0 1.1 1.2 Tadrous, Paul.J. Diagnostic Criteria Handbook in Histopathology: A Surgical Pathology Vade Mecum (1st ed.). Wiley. pp. 138. ISBN 978-0470519035.
- ↑ 2.0 2.1 2.2 Daum, O.; Hatlova, J.; Mandys, V.; Grossmann, P.; Mukensnabl, P.; Benes, Z.; Michal, M. (May 2010). "Comparison of morphological, immunohistochemical, and molecular genetic features of inflammatory fibroid polyps (Vanek's tumors).". Virchows Arch 456 (5): 491-7. doi:10.1007/s00428-010-0914-8. PMID 20393746.
- ↑ Iacobuzio-Donahue, Christine A.; Montgomery, Elizabeth A. (2005). Gastrointestinal and Liver Pathology: A Volume in the Foundations in Diagnostic Pathology Series (1st ed.). Churchill Livingstone. pp. 115. ISBN 978-0443066573.
- ↑ URL: http://dictionary.reference.com/browse/concentric. Accessed on: 29 November 2011.
- ↑ Kolodziejczyk, P.; Yao, T.; Tsuneyoshi, M. (Nov 1993). "Inflammatory fibroid polyp of the stomach. A special reference to an immunohistochemical profile of 42 cases.". Am J Surg Pathol 17 (11): 1159-68. PMID 8214261.
- ↑ Ozolek, JA.; Sasatomi, E.; Swalsky, PA.; Rao, U.; Krasinskas, A.; Finkelstein, SD. (Mar 2004). "Inflammatory fibroid polyps of the gastrointestinal tract: clinical, pathologic, and molecular characteristics.". Appl Immunohistochem Mol Morphol 12 (1): 59-66. PMID 15163021.