Difference between revisions of "Pilomatricoma"

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| Micro      = "ghost" cells, foreign body-type giant cells
| Micro      = "ghost" cells, foreign body-type giant cells
| Subtypes  =
| Subtypes  =
| LMDDx      =
| LMDDx      = [[squamous cell carcinoma]], pilomatrix carcinoma, [[basal cell carcinoma]], [[epidermal inclusion cyst]]
| Stains    =
| Stains    =
| IHC        =
| IHC        =
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It is also known as '''calcifying epithelioma of Malherbe'''.<ref>{{Ref Derm|387}}</ref>
It is also known as '''calcifying epithelioma of Malherbe'''.<ref>{{Ref Derm|387}}</ref>
===General===
==General==
*Benign skin tumour.
*Benign skin tumour.
*Most common solid skin tumour of children.<ref name=emed1058965>URL: [http://emedicine.medscape.com/article/1058965-overview http://emedicine.medscape.com/article/1058965-overview]. Accessed on: 10 September 2011.</ref>
*Most common solid skin tumour of children.<ref name=emed1058965>URL: [http://emedicine.medscape.com/article/1058965-overview http://emedicine.medscape.com/article/1058965-overview]. Accessed on: 10 September 2011.</ref>
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*Surgical excision.<ref name=emed1058965>[http://emedicine.medscape.com/article/1058965-overview http://emedicine.medscape.com/article/1058965-overview]</ref>
*Surgical excision.<ref name=emed1058965>[http://emedicine.medscape.com/article/1058965-overview http://emedicine.medscape.com/article/1058965-overview]</ref>


===Microscopic===
==Microscopic==
Features:<ref name=emed1058965dx>URL: [http://emedicine.medscape.com/article/1058965-diagnosis http://emedicine.medscape.com/article/1058965-diagnosis]. Accessed on: 10 September 2011.</ref>
Features:<ref name=emed1058965dx>URL: [http://emedicine.medscape.com/article/1058965-diagnosis http://emedicine.medscape.com/article/1058965-diagnosis]. Accessed on: 10 September 2011.</ref>
*Nodular circumscribed lower dermis/subcutaneous adipose lesion; thus, usu. surrounded by connective tissue.
*Nodular circumscribed lower dermis/subcutaneous adipose lesion; thus, usu. surrounded by connective tissue.
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*Keratin a prominent feature on cytology - lots of orange stuff.
*Keratin a prominent feature on cytology - lots of orange stuff.
*May ossify.  
*May ossify.  
Images:
*[http://www.bccancer.bc.ca/HPI/CE/cytotechnology/cytosleuthquiz/nongyne/ngcase02.htm Pilomatrixoma - cytology (bccancer.bc.ca)].
*[http://www.dermrounds.com/photo/1980062:Photo:431 Pilomatrixoma - histology (dermrounds.com)].
*[http://en.wikipedia.org/wiki/File:Pilomatrixoma_-_high_mag.jpg Pilomatrixoma - high mag. (WC)].
*[http://en.wikipedia.org/wiki/File:Pilomatrixoma_-_intermed_mag.jpg Pilomatrixoma - intermed. mag. (WC)].


DDx:
DDx:
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*[[Squamous cell carcinoma]].
*[[Squamous cell carcinoma]].
*[[Basal cell carcinoma]].
*[[Basal cell carcinoma]].
===Images===
<gallery>
Image:Pilomatrixoma_-_high_mag.jpg | Pilomatrixoma - high mag. (WC/Nephron)
Image:Pilomatrixoma_-_intermed_mag.jpg | Pilomatrixoma - intermed. mag. (WC/Nephron)
</gallery>
www:
*[http://www.bccancer.bc.ca/HPI/CE/cytotechnology/cytosleuthquiz/nongyne/ngcase02.htm Pilomatrixoma - cytology (bccancer.bc.ca)].
*[http://www.dermrounds.com/photo/1980062:Photo:431 Pilomatrixoma - histology (dermrounds.com)].


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===Sign out===

Revision as of 15:50, 3 July 2013

Pilomatricoma
Diagnosis in short

Pilomatricoma. H&E stain.
LM "ghost" cells, foreign body-type giant cells
LM DDx squamous cell carcinoma, pilomatrix carcinoma, basal cell carcinoma, epidermal inclusion cyst
Site skin
Signs hard nodule
Symptoms +/-painful
Prognosis benign

Pilomatricoma is a benign skin lesion that is common in childhood. It may be spelled pilomatrixoma.

It is also known as calcifying epithelioma of Malherbe.[1]

General

  • Benign skin tumour.
  • Most common solid skin tumour of children.[2]
  • CTNNB1 gene mutation important in pathogenesis.[3]

Clinical:

  • Hard nodule - calcification.
  • +/-Painful.

Treatment:

  • Surgical excision.[2]

Microscopic

Features:[4]

  • Nodular circumscribed lower dermis/subcutaneous adipose lesion; thus, usu. surrounded by connective tissue.
    • Sharpy demarcated island of cells.
    • Calcification in 75%.
  • Cells:[5]
    • Basaloid epithelial cells - have prominent nucleoli.
    • Anucleate squamous cells ("ghost cells").
    • Giant cell foreign body type granulomas (form in reaction to keratin).

Notes:

  • Keratin a prominent feature on cytology - lots of orange stuff.
  • May ossify.

DDx:

Images

  • Pilomatrixoma - high mag. (WC/Nephron)

  • Pilomatrixoma - intermed. mag. (WC/Nephron)

www:

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SKIN LESION, RIGHT ARM, EXCISION:
- PILOMATRICOMA.

See also

References

  1. ↑ Busam, Klaus J. (2009). Dermatopathology: A Volume in the Foundations in Diagnostic Pathology Series (1st ed.). Saunders. pp. 387. ISBN 978-0443066542.
  2. ↑ 2.0 2.1 URL: http://emedicine.medscape.com/article/1058965-overview. Accessed on: 10 September 2011. Cite error: Invalid <ref> tag; name "emed1058965" defined multiple times with different content
  3. ↑ Mitchell, Richard; Kumar, Vinay; Fausto, Nelson; Abbas, Abul K.; Aster, Jon (2011). Pocket Companion to Robbins & Cotran Pathologic Basis of Disease (8th ed.). Elsevier Saunders. pp. 597. ISBN 978-1416054542.
  4. ↑ URL: http://emedicine.medscape.com/article/1058965-diagnosis. Accessed on: 10 September 2011.
  5. ↑ http://www.bccancer.bc.ca/HPI/CE/cytotechnology/cytosleuthquiz/nongyne/ngcase02d.htm
  6. ↑ Busam, Klaus J. (2009). Dermatopathology: A Volume in the Foundations in Diagnostic Pathology Series (1st ed.). Saunders. pp. 389. ISBN 978-0443066542.
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