Difference between revisions of "Liver neoplasms"

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Liver neoplasms (view source)

Revision as of 02:42, 24 May 2013

205 bytes removed ,  02:42, 24 May 2013
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| CK7+, CK19+
| CK7+, CK19+
| background usu. not cirrhotic
| background usu. not cirrhotic
| [http://commons.wikimedia.org/wiki/File:Cholangiocarcinoma.png gross (WC)]
| [[Image:Cholangiocarcinoma.png|thumb|center|150px| Cholangiocarcinoma. (WC)]
|}
|}


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*No cirrhosis!  If cirrhosis is present it isn't a hepatic adenoma - '''important'''.
*No cirrhosis!  If cirrhosis is present it isn't a hepatic adenoma - '''important'''.


Images:
====Images====
*[http://commons.wikimedia.org/wiki/File:Hepatic_adenoma_low_mag.jpg Hepatic adenoma (WC)].
<gallery>
*[http://commons.wikimedia.org/wiki/File:Hepatic_adenoma_low_mag_reticulin.jpg Hepatic adenoma - reticulin (WC)].
Image:Hepatic_adenoma_low_mag.jpg | Hepatic adenoma. (WC/Nephron)
Image:Hepatic_adenoma_low_mag_reticulin.jpg | Hepatic adenoma - reticulin. (WC/Nephron)
</gallery>
www:
*[http://www.ajronline.org/cgi/content-nw/full/182/6/1520/FIG3 Hepatic adenoma (ajronline.org)].
*[http://www.ajronline.org/cgi/content-nw/full/182/6/1520/FIG3 Hepatic adenoma (ajronline.org)].
*[http://radiographics.rsna.org/content/22/5/1023.figures-only Series of liver micrographs including hepatic adenoma (radiographics.rsna.org)].
*[http://radiographics.rsna.org/content/22/5/1023.figures-only Series of liver micrographs including hepatic adenoma (radiographics.rsna.org)].
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*[[Hepatocellular carcinoma]] - separated based on histomorphology alone.
*[[Hepatocellular carcinoma]] - separated based on histomorphology alone.


Images:
====Images====
*[http://commons.wikimedia.org/wiki/File:Hepatoblastoma_-_2_-_very_high_mag.jpg Hepatoblastoma - very high mag. (WC)].
<gallery>
*[http://commons.wikimedia.org/wiki/File:Hepatoblastoma_-_high_mag.jpg Hepatoblastoma - high mag. (WC)].
Image:Hepatoblastoma_-_2_-_very_high_mag.jpg | Hepatoblastoma - very high mag. (WC/Nephron)
Image:Hepatoblastoma_-_high_mag.jpg | Hepatoblastoma - high mag. (WC/Nephron)
</gallery>


====Subtypes====
====Subtypes====
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*Combined HCC-CC.<ref name=pmid21559202>{{Cite journal  | last1 = Walther | first1 = Z. | last2 = Jain | first2 = D. | title = Molecular pathology of hepatic neoplasms: classification and clinical significance. | journal = Patholog Res Int | volume = 2011 | issue =  | pages = 403929 | month =  | year = 2011 | doi = 10.4061/2011/403929 | PMID = 21559202 | PMC = 3090128 }}</ref>
*Combined HCC-CC.<ref name=pmid21559202>{{Cite journal  | last1 = Walther | first1 = Z. | last2 = Jain | first2 = D. | title = Molecular pathology of hepatic neoplasms: classification and clinical significance. | journal = Patholog Res Int | volume = 2011 | issue =  | pages = 403929 | month =  | year = 2011 | doi = 10.4061/2011/403929 | PMID = 21559202 | PMC = 3090128 }}</ref>


Images:
====Images====
*[http://commons.wikimedia.org/wiki/File:Hepatocellular_carcinoma_low_mag.jpg HCC - low mag. (WC)].
<gallery>
*[http://commons.wikimedia.org/wiki/File:Hepatocellular_carcinoma_intermed_mag.jpg HCC - intermed mag. (WC)].
Image:Hepatocellular_carcinoma_low_mag.jpg | HCC - low mag. (WC)
Image:Hepatocellular_carcinoma_intermed_mag.jpg | HCC - intermed mag. (WC)
</gallery>


====Fibrolamellar hepatocellular carcinoma====
====Fibrolamellar hepatocellular carcinoma====
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*If ''conventional HCC'' is seen focally within the tumour, it is ''conventional HCC''.
*If ''conventional HCC'' is seen focally within the tumour, it is ''conventional HCC''.


Images:
======Images======
*[[WC]]:
<gallery>
**[http://commons.wikimedia.org/wiki/File:Fibrolamellar_hepatocellular_carcinoma_-2-_intermed_mag.jpg FHCC - intermed. mag. (WC)].
Image:Fibrolamellar_hepatocellular_carcinoma_-2-_intermed_mag.jpg | FHCC - intermed. mag. (WC)
**[http://commons.wikimedia.org/wiki/File:Fibrolamellar_hepatocellular_carcinoma_-2-_very_high_mag.jpg FHCC - very high mag. (WC)].
Image:Fibrolamellar_hepatocellular_carcinoma_-2-_very_high_mag.jpg | FHCC - very high mag. (WC)
 
</gallery>
====Sclerosing HCC====
====Sclerosing HCC====
Features:
Features:
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**May have satellite nodules.
**May have satellite nodules.


Image:
====Image====
*[http://commons.wikimedia.org/wiki/File:Cholangiocarcinoma.png Cholangiocarcinoma (WC)].
<gallery>
 
Image:Cholangiocarcinoma.png | Cholangiocarcinoma. (WC)
</gallery>
===Microscopic===
===Microscopic===
Features:<ref name=Ref_GLP609>{{Ref GLP|609}}</ref>
Features:<ref name=Ref_GLP609>{{Ref GLP|609}}</ref>
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**No necrosis, no mitotic activity, no significant [[nuclear pleomorphism]].
**No necrosis, no mitotic activity, no significant [[nuclear pleomorphism]].


Images:
====Images====
*[[WC]]:
<gallery>
**[http://commons.wikimedia.org/wiki/File:Cholangiocarcinoma_-_low_mag.jpg Cholangiocarcinoma - low mag. (WC)] - the image shows the typical demosplastic stroma.
Image:Cholangiocarcinoma_-_low_mag.jpg | Cholangiocarcinoma - low mag. Shows the typical [[demosplastic stroma]]. (WC/Nephron)
**[http://commons.wikimedia.org/wiki/File:Cholangiocarcinoma_-_high_mag.jpg Cholangiocarcinoma - high mag. (WC)] - the image shows a normal portal triad adjacent to atypical glandular cells within the interlobular septum and obvious tumour.
Image:Cholangiocarcinoma_-_high_mag.jpg |Cholangiocarcinoma - high mag. Shows a normal portal triad adjacent to atypical glandular cells within the interlobular septum and obvious tumour. (WC/Nephron)
*www:
</gallery>
**[http://path.upmc.edu/cases/case296.html Cholangiocarcinoma & liver flukes - several images (upmc.edu)].
www:
**[http://path.upmc.edu/cases/case420.html Cholangiocarcinoma - several images (upmc.edu)].
*[http://path.upmc.edu/cases/case296.html Cholangiocarcinoma & liver flukes - several images (upmc.edu)].
*[http://path.upmc.edu/cases/case420.html Cholangiocarcinoma - several images (upmc.edu)].


===IHC===
===IHC===
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*Gland forming columnar shaped cells with pseudostratified hyperchromatic cigar-shaped nuclei.
*Gland forming columnar shaped cells with pseudostratified hyperchromatic cigar-shaped nuclei.


Image:
====Image====
*[http://commons.wikimedia.org/wiki/File:Adenocarcinoma_liver_metastasis.jpg Liver metastasis - adenocarcinoma, not obviously CRC (WC)].
<gallery>
Image:Adenocarcinoma_liver_metastasis.jpg | Liver metastasis - adenocarcinoma, not obviously CRC (WC)].
</gallery>


===IHC===
===IHC===
Michael
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