Difference between revisions of "Non-small cell lung carcinoma"

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It can be understood as a synonym for ''large cell carcinoma'' which is umbrella term that includes [[squamous cell carcinoma of lung]] and [[adenocarcinoma of the lung]].
It can be understood as a synonym for ''large cell carcinoma'' which is umbrella term that includes [[squamous cell carcinoma of lung]] and [[adenocarcinoma of the lung]].
==IHC==
Sloan-Kettering algorithm - Rekhtman ''et al.'':<ref name=pmid21623384>{{Cite journal  | last1 = Rekhtman | first1 = N. | last2 = Ang | first2 = DC. | last3 = Sima | first3 = CS. | last4 = Travis | first4 = WD. | last5 = Moreira | first5 = AL. | title = Immunohistochemical algorithm for differentiation of lung adenocarcinoma and squamous cell carcinoma based on large series of whole-tissue sections with validation in small specimens. | journal = Mod Pathol | volume = 24 | issue = 10 | pages = 1348-59 | month = Oct | year = 2011 | doi = 10.1038/modpathol.2011.92 | PMID = 21623384 }}</ref>
{| class="wikitable sortable"
! TTF-1\p63
! p63 -ve (0% of cells)
! p63 +ve <50% of cells
! p63 +ve >=50% of cells
|-
| TTF-1 +ve >=50% of cells
| Adenocarcinoma
| Adenocarcinoma
| Adenocarcinoma
|-
| TTF-1 +ve <50% of cells
| Adenocarcinoma
| Adenocarcinoma
| Squamous carcinoma
|-
| TTF-1 -ve (0% of cells)
| Adenocarcinoma
| CK5/6 to determine
| Squamous carcinoma
|}


==See also==
==See also==
*[[Lung tumours]].
*[[Lung tumours]].
==References==
{{Reflist|1}}


[[Category:Pulmonary pathology]]
[[Category:Pulmonary pathology]]

Revision as of 00:08, 3 May 2013

Non-small cell lung carcinoma, abbreviated NSCLC, is a malignant epithelial neoplasm that is not small cell carcinoma of the lung.

It can be understood as a synonym for large cell carcinoma which is umbrella term that includes squamous cell carcinoma of lung and adenocarcinoma of the lung.

IHC

Sloan-Kettering algorithm - Rekhtman et al.:[1]

TTF-1\p63 p63 -ve (0% of cells) p63 +ve <50% of cells p63 +ve >=50% of cells
TTF-1 +ve >=50% of cells Adenocarcinoma Adenocarcinoma Adenocarcinoma
TTF-1 +ve <50% of cells Adenocarcinoma Adenocarcinoma Squamous carcinoma
TTF-1 -ve (0% of cells) Adenocarcinoma CK5/6 to determine Squamous carcinoma

See also

References

  1. Rekhtman, N.; Ang, DC.; Sima, CS.; Travis, WD.; Moreira, AL. (Oct 2011). "Immunohistochemical algorithm for differentiation of lung adenocarcinoma and squamous cell carcinoma based on large series of whole-tissue sections with validation in small specimens.". Mod Pathol 24 (10): 1348-59. doi:10.1038/modpathol.2011.92. PMID 21623384.