Difference between revisions of "Epstein-Barr virus-associated smooth muscle tumour"

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'''[[Epstein-Barr virus]]-associated smooth muscle tumour''' is a very uncommon [[soft tissue lesions|soft tissue lesion]].<ref name=pmid16330945>{{Cite journal  | last1 = Deyrup | first1 = AT. | last2 = Lee | first2 = VK. | last3 = Hill | first3 = CE. | last4 = Cheuk | first4 = W. | last5 = Toh | first5 = HC. | last6 = Kesavan | first6 = S. | last7 = Chan | first7 = EW. | last8 = Weiss | first8 = SW. | title = Epstein-Barr virus-associated smooth muscle tumors are distinctive mesenchymal tumors reflecting multiple infection events: a clinicopathologic and molecular analysis of 29 tumors from 19 patients. | journal = Am J Surg Pathol | volume = 30 | issue = 1 | pages = 75-82 | month = Jan | year = 2006 | doi =  | PMID = 16330945 }}</ref>
'''[[Epstein-Barr virus]]-associated smooth muscle tumour''', abbreviated '''EBV-SMT''', is a very uncommon [[soft tissue lesions|soft tissue lesion]].<ref name=pmid16330945>{{Cite journal  | last1 = Deyrup | first1 = AT. | last2 = Lee | first2 = VK. | last3 = Hill | first3 = CE. | last4 = Cheuk | first4 = W. | last5 = Toh | first5 = HC. | last6 = Kesavan | first6 = S. | last7 = Chan | first7 = EW. | last8 = Weiss | first8 = SW. | title = Epstein-Barr virus-associated smooth muscle tumors are distinctive mesenchymal tumors reflecting multiple infection events: a clinicopathologic and molecular analysis of 29 tumors from 19 patients. | journal = Am J Surg Pathol | volume = 30 | issue = 1 | pages = 75-82 | month = Jan | year = 2006 | doi =  | PMID = 16330945 }}</ref>


==General==
==General==
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*[[Leiomyosarcoma]].
*[[Leiomyosarcoma]].
*[[Leiomyoma]].
*[[Leiomyoma]].
Image:
*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2996495/figure/Fig2/ EBV-EMT (nih.gov)].<ref name=pmid20690046>{{Cite journal  | last1 = Huang | first1 = J. | last2 = Loh | first2 = KS. | last3 = Petersson | first3 = F. | title = Epstein-barr virus-associated smooth muscle tumor of the larynx: report of a rare case mimicking leiomyosarcoma. | journal = Head Neck Pathol | volume = 4 | issue = 4 | pages = 300-4 | month = Dec | year = 2010 | doi = 10.1007/s12105-010-0201-7 | PMID = 20690046 }}
</ref>
==Stains==
*EBER +ve.<ref name=pmid20690046/>


==IHC==
==IHC==
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*CD34 -ve.
*CD34 -ve.
*CD117 -ve.
*CD117 -ve.
Image:
*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2996495/figure/Fig4/ EBV-SMT (nih.gov)].


==References==
==References==

Revision as of 03:20, 4 March 2013

Epstein-Barr virus-associated smooth muscle tumour, abbreviated EBV-SMT, is a very uncommon soft tissue lesion.[1]

General

Microscopic

Features:[1]

  • Smooth muscle lesion:
    • Spindle cells in a fascicular arrangement.
    • Usually minimal nuclear atypia and few mitoses.
  • Lymphocytes.

DDx:

Image:

Stains

IHC

  • SMA +ve
  • Desmin +ve/-ve.
  • CD34 -ve.
  • CD117 -ve.

Image:

References

  1. ↑ 1.0 1.1 Deyrup, AT.; Lee, VK.; Hill, CE.; Cheuk, W.; Toh, HC.; Kesavan, S.; Chan, EW.; Weiss, SW. (Jan 2006). "Epstein-Barr virus-associated smooth muscle tumors are distinctive mesenchymal tumors reflecting multiple infection events: a clinicopathologic and molecular analysis of 29 tumors from 19 patients.". Am J Surg Pathol 30 (1): 75-82. PMID 16330945.
  2. ↑ 2.0 2.1 Huang, J.; Loh, KS.; Petersson, F. (Dec 2010). "Epstein-barr virus-associated smooth muscle tumor of the larynx: report of a rare case mimicking leiomyosarcoma.". Head Neck Pathol 4 (4): 300-4. doi:10.1007/s12105-010-0201-7. PMID 20690046.
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