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Difference between revisions of "Small cell lymphomas"
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→Follicular lymphoma: +SO
(→Follicular lymphoma: +SO) |
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*t(14;18)(q32;q21)/IGH-BCL2 in 70-95% of cases.<ref name=pmid18359244/> | *t(14;18)(q32;q21)/IGH-BCL2 in 70-95% of cases.<ref name=pmid18359244/> | ||
**Should not be confused with t(14;18)(q32;q21)/IGH-MALT1 seen in MALT lymphomas.<ref name=pmid16950858>{{cite journal |author=Bacon CM, Du MQ, Dogan A |title=Mucosa-associated lymphoid tissue (MALT) lymphoma: a practical guide for pathologists |journal=J. Clin. Pathol. |volume=60 |issue=4 |pages=361–72 |year=2007 |month=April |pmid=16950858 |pmc=2001121 |doi=10.1136/jcp.2005.031146 |url=}}</ref> | **Should not be confused with t(14;18)(q32;q21)/IGH-MALT1 seen in MALT lymphomas.<ref name=pmid16950858>{{cite journal |author=Bacon CM, Du MQ, Dogan A |title=Mucosa-associated lymphoid tissue (MALT) lymphoma: a practical guide for pathologists |journal=J. Clin. Pathol. |volume=60 |issue=4 |pages=361–72 |year=2007 |month=April |pmid=16950858 |pmc=2001121 |doi=10.1136/jcp.2005.031146 |url=}}</ref> | ||
===Sign out=== | |||
<pre> | |||
RETROPERITONEAL MASS, RIGHT, CORE BIOPSIES: | |||
- NON-HODGKIN B-CELL LYMPHOMA, FAVOUR FOLLICULAR LYMPHOMA. | |||
COMMENT: | |||
Morphology: | |||
-Small cells: size ~ mature lymphocytes, quantity - many, angular and round. | |||
-Large cells (intermixed with small cells): size ~1.5-2x mature lymphocyte, | |||
small nucleoli, moderate quantity of grey/basophilic cytoplasm, moderate | |||
nuclear pleomorphism. | |||
-Architecture: no gland formation, discohesive, no follicles apparent, no sheets | |||
of large cells. | |||
-Mitoses are uncommon. | |||
Immunohistochemical stains (tumour cells): | |||
Positive: CD45 (strong, membranous/cytoplasmic), CD20 (strong, membranous/cytoplasmic), | |||
BCL-2 (strong, membranous/cytoplasmic), CD10 (strong, membranous), BCL-6 (moderate, | |||
patchy, nuclear). | |||
Negative: pankeratin, CD3, CD5, CD30, CD21 (follicular dendritic cells not apparent), | |||
CD23 (scattered, rare). | |||
Ki-67: highlights the large cells, primarily -- 5-35% of cells within the core. | |||
The findings favour a follicular lymphoma, based on the cellular morphology and | |||
immunostains; however, they are limited by the type of tissue sampling (core biopsy). | |||
Clinical correlation is suggested. | |||
</pre> | |||
==Mantle cell lymphoma== | ==Mantle cell lymphoma== | ||