Difference between revisions of "Urothelium"

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Urothelium (view source)

Revision as of 01:09, 28 November 2012

1 byte added ,  01:09, 28 November 2012
→‎Papillary urothelial lesions: format
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Urothelial cells in papillae - benign/premalignant/cancerous:<ref>{{Ref GUP|166-175}}</ref><ref name=Ref_WMSP310>{{Ref WMSP|310}}</ref>
Urothelial cells in papillae - benign/premalignant/cancerous:<ref>{{Ref GUP|166-175}}</ref><ref name=Ref_WMSP310>{{Ref WMSP|310}}</ref>
{| class="wikitable"
{| class="wikitable"
| ||'''Papilloma''' ||'''PUNLMP''' ||'''low grade PUCC''' ||'''high grade PUCC'''
|
|'''Papilloma'''
|'''PUNLMP'''
|'''low grade PUCC'''
|'''high grade PUCC'''
|-
|-
|papillae features ||'''fat papillae''', <br>'''thick FV core''' ||'''slender FV core''' ||slender FV core, <br>'''thick epithelium''' ||mixed population
|papillae features
|'''fat papillae''', <br>'''thick FV core'''
|'''slender FV core'''
|slender FV core, <br>'''thick epithelium'''
|mixed population
|-
|-
|papillae branching ||rare ||uncommon ||frequent ||common
|papillae branching
|rare
|uncommon
|frequent
|common
|-
|-
|papillae fusion ||none ||rare ||some ||common
|papillae fusion
|none
|rare
|some
|common
|-
|-
|nuclear size ||normal (2x lymphocyte) ||'''enlarged - uniform''' ||'''enlarged with variation''' ||'''4-5x lymphocyte,'''<br>'''marked pleomorphism'''
|nuclear size
|normal (2x lymphocyte) |
|'''enlarged - uniform'''
|'''enlarged with variation'''
|'''4-5x lymphocyte,'''<br>'''marked pleomorphism'''
|-
|-
|mitoses ||very rare basal || rare basal only ||infreq., usually basal ||common, everywhere
|mitoses
|very rare basal
| rare basal only
|infreq., usually basal
|common, everywhere
|-
|-
|DDx ||PUNLMP, low gr. PUCC ||papilloma, low gr. ||PUNLMP, high gr. ||low gr., invasive UCC
|DDx
|PUNLMP, low gr. PUCC
|papilloma, low gr.
|PUNLMP, high gr.
|low gr., invasive UCC
|-
|-
|IHC ||p53-, CK20+ umbrella cells ||CK20+ umbrella ||-/+ p53, CK20+ umbrella ||'''diffuse CK20+''', p53+ in 50%
|IHC
|p53-, CK20+ umbrella cells
|CK20+ umbrella
|-/+ p53, CK20+ umbrella
|'''diffuse CK20+''', p53+ in 50%
|-
|-
|Other ||cytologically normal ||low cellular density (@ low power) vs. low gr.<ref>GAG. 26 February 2009.</ref> ||+/- small nucleoli ||nucleoli prominent
|Other
|cytologically normal
|low cellular density (@ low power) vs. low gr.<ref>GAG. 26 February 2009.</ref>
|+/- small nucleoli
|nucleoli prominent
|-
|-
|Key feature ||normal cells,<br>fat papillae ||uniformly enlarged cell pop., <br>slender papillae ||nuc. pleomorphism, <br> thick epithelium ||marked nuclear pleomorphism
|Key feature
|normal cells,<br>fat papillae
|uniformly enlarged cell pop., <br>slender papillae  
|nuc. pleomorphism, <br> thick epithelium
|marked nuclear pleomorphism
|-
|-
|}
|}
Michael
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