Difference between revisions of "Signet ring cell carcinoma"

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*[[Serous fat atrophy]].<ref name=pmid6222282>{{Cite journal  | last1 = Clarke | first1 = BE. | last2 = Brown | first2 = DJ. | last3 = Xipell | first3 = JM. | title = Gelatinous transformation of the bone marrow. | journal = Pathology | volume = 15 | issue = 1 | pages = 85-8 | month = Jan | year = 1983 | doi =  | PMID = 6222282 }}</ref>
*[[Serous fat atrophy]].<ref name=pmid6222282>{{Cite journal  | last1 = Clarke | first1 = BE. | last2 = Brown | first2 = DJ. | last3 = Xipell | first3 = JM. | title = Gelatinous transformation of the bone marrow. | journal = Pathology | volume = 15 | issue = 1 | pages = 85-8 | month = Jan | year = 1983 | doi =  | PMID = 6222282 }}</ref>
*[[Mucocele]] - muciphages may mimic signet ring cells.<ref name=pmid9591723>{{Cite journal  | last1 = De Petris | first1 = G. | last2 = Lev | first2 = R. | last3 = Siew | first3 = S. | title = Peritumoral and nodal muciphages. | journal = Am J Surg Pathol | volume = 22 | issue = 5 | pages = 545-9 | month = May | year = 1998 | doi =  | PMID = 9591723 }}</ref>
*[[Mucocele]] - muciphages may mimic signet ring cells.<ref name=pmid9591723>{{Cite journal  | last1 = De Petris | first1 = G. | last2 = Lev | first2 = R. | last3 = Siew | first3 = S. | title = Peritumoral and nodal muciphages. | journal = Am J Surg Pathol | volume = 22 | issue = 5 | pages = 545-9 | month = May | year = 1998 | doi =  | PMID = 9591723 }}</ref>
**Muciphages = cytoplasm lightly eosinophilic, multivaculated (classic) or finely reticulated.


Images:
Images:

Revision as of 15:14, 24 September 2012

Signet ring cell carcinoma, abbreviated SRCC, is a type of malignant epithelial neoplasm that typically arises from the stomach.

General

  • It has been said that there are two types of pathologists... those that have missed SRCCs and those that will miss SRCCs.

Differential diagnosis

It may arise from the:[1]

Microscopic

Features:

  • Signet ring cells resemble signet rings.
    • They contain a large amount of mucin, which pushes the nucleus to the cell periphery.
    • The pool of mucin in a signet ring cell mimics the appearance of the finger hole.
    • The nucleus mimics the appearance of the face of the ring in profile.
  • Signet ring cells are typically 2-3x the size of a lymphocyte.
    • Smaller than the typical adipocyte.
  • Often have a crescent-shaped or ovoid nucleus.
    • Capillaries sectioned on their lumen have endothelial cells - the nuclei of these are more spindled.

Note:

  • SRCs are usually close to friend, i.e. they are adjacent to another SRC.
    • This helps differentiate SRCs from capillaries sectioned on their lumen.
  • The mucin is often clear on H&E... but maybe eosinophilic.

DDx:

  • Serous fat atrophy.[2]
  • Mucocele - muciphages may mimic signet ring cells.[3]
    • Muciphages = cytoplasm lightly eosinophilic, multivaculated (classic) or finely reticulated.

Images:

Stains

  • PAS stain +ve.
  • Alican blue-PAS stain +ve.

IHC

  • AE1/AE3 +ve.
  • CK7 +ve.

See also

References

  1. ↑ URL: http://cancerhelp.cancerresearchuk.org/about-cancer/cancer-questions/what-is-a-signet-cell-cancer. Accessed on: 7 March 2012.
  2. ↑ Clarke, BE.; Brown, DJ.; Xipell, JM. (Jan 1983). "Gelatinous transformation of the bone marrow.". Pathology 15 (1): 85-8. PMID 6222282.
  3. ↑ De Petris, G.; Lev, R.; Siew, S. (May 1998). "Peritumoral and nodal muciphages.". Am J Surg Pathol 22 (5): 545-9. PMID 9591723.
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