Difference between revisions of "Hemolytic uremic syndrome"

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'''Hemolytic uremic syndrome''', abbreviated '''HUS''', is the triad of:<ref>URL: [http://emedicine.medscape.com/article/779218-overview http://emedicine.medscape.com/article/779218-overview]. Accessed on: 8 September 2010.</ref>
'''Hemolytic uremic syndrome''', abbreviated '''HUS''', is the triad of:<ref>URL: [http://emedicine.medscape.com/article/779218-overview http://emedicine.medscape.com/article/779218-overview]. Accessed on: 8 September 2010.</ref>
*Microangiopathic hemolytic anemia.
*Microangiopathic hemolytic anemia; microangiopathic<ref>URL: [http://www.mercksource.com/pp/us/cns/cns_hl_dorlands_split.jsp?pg=/ppdocs/us/common/dorlands/dorland/one/000005089.htm http://www.mercksource.com/pp/us/cns/cns_hl_dorlands_split.jsp?pg=/ppdocs/us/common/dorlands/dorland/one/000005089.htm]. Accessed on: 9 September 2010.</ref> = disease affecting small blood vessels.
*Thrombocytopenia.  
*Thrombocytopenia; low platelet count.  
*Acute renal failure.
*Acute renal failure.


==Etiology==
==Etiology==
*Verotoxins (from ''E. coli'' O157:H7) --> endothelial injury.<ref name=pmid19180125>{{cite journal |author=Petruzziello TN, Mawji IA, Khan M, Marsden PA |title=Verotoxin biology: molecular events in vascular endothelial injury |journal=Kidney Int. Suppl. |volume= |issue=112 |pages=S17–9 |year=2009 |month=February |pmid=19180125 |doi=10.1038/ki.2008.612 |url=}}</ref>
*Rare (uncooked) hamburger.
*''E. coli'' serotype O157:H7.
**Verotoxins from ''E. coli'' O157:H7 --> endothelial injury.<ref name=pmid19180125>{{cite journal |author=Petruzziello TN, Mawji IA, Khan M, Marsden PA |title=Verotoxin biology: molecular events in vascular endothelial injury |journal=Kidney Int. Suppl. |volume= |issue=112 |pages=S17–9 |year=2009 |month=February |pmid=19180125 |doi=10.1038/ki.2008.612 |url=}}</ref>


==Relation to thrombotic thrombocytopenic purpura (TTP)==
==Relation to thrombotic thrombocytopenic purpura (TTP)==
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**It is classically characterized by: microangiopathic hemolytic anemia, thrombocytopenia, fever, mild renal failure, and prominent neurologic symptoms.
**It is classically characterized by: microangiopathic hemolytic anemia, thrombocytopenia, fever, mild renal failure, and prominent neurologic symptoms.
*Both are classified as ''thrombotic microangiopathies''.<ref>URL: [http://emedicine.medscape.com/article/779218-overview http://emedicine.medscape.com/article/779218-overview]. Accessed on: 8 September 2010.</ref>
*Both are classified as ''thrombotic microangiopathies''.<ref>URL: [http://emedicine.medscape.com/article/779218-overview http://emedicine.medscape.com/article/779218-overview]. Accessed on: 8 September 2010.</ref>
==Etiology==
*Rare hamburger.
*E. coli serotype O157:H7.


==See also==
==See also==

Revision as of 19:38, 9 September 2010

Hemolytic uremic syndrome, abbreviated HUS, is the triad of:[1]

  • Microangiopathic hemolytic anemia; microangiopathic[2] = disease affecting small blood vessels.
  • Thrombocytopenia; low platelet count.
  • Acute renal failure.

Etiology

  • Rare (uncooked) hamburger.
  • E. coli serotype O157:H7.
    • Verotoxins from E. coli O157:H7 --> endothelial injury.[3]

Relation to thrombotic thrombocytopenic purpura (TTP)

  • TTP is the main (clinical) DDx of HUS.
    • It is classically characterized by: microangiopathic hemolytic anemia, thrombocytopenia, fever, mild renal failure, and prominent neurologic symptoms.
  • Both are classified as thrombotic microangiopathies.[4]

See also

References

  1. URL: http://emedicine.medscape.com/article/779218-overview. Accessed on: 8 September 2010.
  2. URL: http://www.mercksource.com/pp/us/cns/cns_hl_dorlands_split.jsp?pg=/ppdocs/us/common/dorlands/dorland/one/000005089.htm. Accessed on: 9 September 2010.
  3. Petruzziello TN, Mawji IA, Khan M, Marsden PA (February 2009). "Verotoxin biology: molecular events in vascular endothelial injury". Kidney Int. Suppl. (112): S17–9. doi:10.1038/ki.2008.612. PMID 19180125.
  4. URL: http://emedicine.medscape.com/article/779218-overview. Accessed on: 8 September 2010.