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Difference between revisions of "Hemolytic uremic syndrome"
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Hemolytic uremic syndrome (view source)
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'''Hemolytic uremic syndrome''' is the triad of:<ref>URL: [http://emedicine.medscape.com/article/779218-overview http://emedicine.medscape.com/article/779218-overview]. Accessed on: 8 September 2010.</ref> | '''Hemolytic uremic syndrome''', abbreviated '''HUS''', is the triad of:<ref>URL: [http://emedicine.medscape.com/article/779218-overview http://emedicine.medscape.com/article/779218-overview]. Accessed on: 8 September 2010.</ref> | ||
*Microangiopathic hemolytic anemia. | *Microangiopathic hemolytic anemia. | ||
*Thrombocytopenia. | *Thrombocytopenia. | ||
*Acute renal failure. | *Acute renal failure. | ||
== | ==Etiology== | ||
*Verotoxins (from ''E. coli'' O157:H7) --> endothelial injury.<ref name=pmid19180125>{{cite journal |author=Petruzziello TN, Mawji IA, Khan M, Marsden PA |title=Verotoxin biology: molecular events in vascular endothelial injury |journal=Kidney Int. Suppl. |volume= |issue=112 |pages=S17–9 |year=2009 |month=February |pmid=19180125 |doi=10.1038/ki.2008.612 |url=}}</ref> | |||
* | |||
==Relation to thrombotic thrombocytopenic purpura (TTP)== | |||
*TTP is the main (clinical) DDx of HUS. | |||
**It is classically characterized by: microangiopathic hemolytic anemia, thrombocytopenia, fever, mild renal failure, and prominent neurologic symptoms. | |||
*Both are classified as ''thrombotic microangiopathies''.<ref>URL: [http://emedicine.medscape.com/article/779218-overview http://emedicine.medscape.com/article/779218-overview]. Accessed on: 8 September 2010.</ref> | |||
==Etiology== | ==Etiology== | ||
*Rare hamburger. | *Rare hamburger. | ||
*E coli serotype O157:H7. | *E. coli serotype O157:H7. | ||
==See also== | ==See also== | ||