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Difference between revisions of "Malignant melanoma"
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→Skin: margin assessment
(→Skin: margin assessment) |
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*IV = extends into reticular dermis. | *IV = extends into reticular dermis. | ||
*V = extends into subdermis. | *V = extends into subdermis. | ||
====Margin assessment==== | |||
{{Main|Surgical margin}} | |||
Margin assessment is notoriously difficult as there are numerous mimics of melanoma in situ:<ref name=pmid21549242>{{Cite journal | last1 = Trotter | first1 = MJ. | title = Melanoma margin assessment. | journal = Clin Lab Med | volume = 31 | issue = 2 | pages = 289-300 | month = Jun | year = 2011 | doi = 10.1016/j.cll.2011.03.006 | PMID = 21549242 }}</ref> | |||
*Melanocytic hyperplasia (considered to be on a continuum with melanoma) may be due to: | |||
**Light exposure. | |||
**Peritumoral-effect. | |||
**Previous biopsy. | |||
*Solar lentigo. | |||
*Lichenoid reaction. | |||
Features of [[MIS]]:<ref name=pmid21549242/> | |||
#Pagetoid spread of melanocytes. | |||
#Junctional or intraepidermal melanocytic nests. | |||
#Three of more contiguous melanocytes in the basal layer. | |||
#Increased numbers of basal melanocytes ( > 25 melanocytes / 0.5 mm of basal layer). | |||
#Marked cytologic atypia - multinucleated cells. | |||
#Adenxal involvement. | |||
=====Margin adequacy===== | |||
:''See [[Surgical_margins#Adequate_margins_by_tumour]]''. | |||
====Subtypes==== | ====Subtypes==== | ||