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Difference between revisions of "Melanocytic lesions"
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→Grading: more
(→Clark nevus: nucleoli -- size) |
(→Grading: more) |
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| Line 323: | Line 323: | ||
| Mild | | Mild | ||
| 1x keratinocyte nucleus | | 1x keratinocyte nucleus | ||
| no nucleoli/very small nucleoli,<ref name=pmid12920220>{{Cite journal | last1 = Arumi-Uria | first1 = M. | last2 = McNutt | first2 = NS. | last3 = Finnerty | first3 = B. | title = Grading of atypia in nevi: correlation with melanoma risk. | journal = Mod Pathol | volume = 16 | issue = 8 | pages = 764-71 | month = Aug | year = 2003 | doi = 10.1097/01.MP.0000082394.91761.E5 | PMID = 12920220 | URL = http://www.nature.com/modpathol/journal/v16/n8/full/3880837a.html }}</ref> slight hyperchromasia | | no nucleoli/very small nucleoli †,<ref name=pmid12920220>{{Cite journal | last1 = Arumi-Uria | first1 = M. | last2 = McNutt | first2 = NS. | last3 = Finnerty | first3 = B. | title = Grading of atypia in nevi: correlation with melanoma risk. | journal = Mod Pathol | volume = 16 | issue = 8 | pages = 764-71 | month = Aug | year = 2003 | doi = 10.1097/01.MP.0000082394.91761.E5 | PMID = 12920220 | URL = http://www.nature.com/modpathol/journal/v16/n8/full/3880837a.html }}</ref> slight hyperchromasia | ||
|- | |- | ||
| Moderate | | Moderate | ||
| 1-2x keratinocyte nucleus | | 1-2x keratinocyte nucleus | ||
| small nucleoli, irregular nuclear contours | | small nucleoli †, irregular nuclear contours | ||
|- | |- | ||
| Severe | | Severe | ||
| >2x keratinocyte nucleus | | >2x keratinocyte nucleus | ||
| prominent nucleoli | | prominent nucleoli †‡ | ||
|} | |} | ||
† Prominent nucleoli (alone) is considered enough to call "severe".<ref name=Ref_Derm447-8>{{Ref Derm|447-8}}</ref> | † The sizes "very small", "small" and "prominent" are not defined; it is suggested that "very small" is visible with the 40x objective, "small" with the 20x objective and "prominent" with the 10x objective.<br> | ||
‡ Prominent nucleoli (alone) is considered enough to call "severe".<ref name=Ref_Derm447-8>{{Ref Derm|447-8}}</ref> | |||
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