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Difference between revisions of "Dermatologic neoplasms"
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nl update 23
(→Microscopic: tweak, fix sp.) |
(nl update 23) |
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Note: | Note: | ||
* † The words used are "hair-bearing lip" - but there is considerable confusion about this as the AJCC manual contradicts itself.<ref name=pmid21151529>{{Cite journal | last1 = Buethe | first1 = D. | last2 = Warner | first2 = C. | last3 = Miedler | first3 = J. | last4 = Cockerell | first4 = CJ. | title = Focus Issue on Squamous Cell Carcinoma: Practical Concerns Regarding the 7th Edition AJCC Staging Guidelines. | journal = J Skin Cancer | volume = 2011 | issue = | pages = 156391 | month = | year = 2011 | doi = 10.1155/2011/156391 | PMID = 21151529 | PMC = 2990020 | URL = http://www.hindawi.com/journals/jsc/2011/156391/ }}</ref> | * † The words used are "hair-bearing lip" - but there is considerable confusion about this as the AJCC manual contradicts itself.<ref name=pmid21151529>{{Cite journal | last1 = Buethe | first1 = D. | last2 = Warner | first2 = C. | last3 = Miedler | first3 = J. | last4 = Cockerell | first4 = CJ. | title = Focus Issue on Squamous Cell Carcinoma: Practical Concerns Regarding the 7th Edition AJCC Staging Guidelines. | journal = J Skin Cancer | volume = 2011 | issue = | pages = 156391 | month = | year = 2011 | doi = 10.1155/2011/156391 | PMID = 21151529 | PMC = 2990020 | URL = http://www.hindawi.com/journals/jsc/2011/156391/ }}</ref> | ||
DDx: | |||
*[[Inverted follicular keratosis]]. | |||
*[[Bowen disease]]. | |||
*[[Malignant melanoma]]. | |||
*[[Paget disease of the breast]]. | |||
*[[Eccrine carcinoma]] | |||
====Bowen disease==== | ====Bowen disease==== | ||
| Line 205: | Line 212: | ||
*Classic appearance of melanoma: | *Classic appearance of melanoma: | ||
**Loosely cohesive; mix of small nests of cells, single cells. | **Loosely cohesive; mix of small nests of cells, single cells. | ||
** | **Usu. mixed of spindle and ovoid cell morphology. | ||
**+/-Occasional large binucleated cells. | **+/-Occasional large binucleated cells. | ||
**Cytoplasm: brown pigment (melanin). | **+/-Cytoplasm: brown pigment (melanin). | ||
**Prominent (large) red nucleoli (like in ''serous carcinoma'' of the ovary). | **+/-Prominent (large) red nucleoli (like in ''serous carcinoma'' of the ovary). | ||
** | **Often marked nuclear pleomorphism - variation in cell size, shape & staining (like in ''serous carcinoma'' of the ovary). | ||
**[[Nuclear pseudoinclusions]] (like in ''papillary thyroid carcinoma''). | **[[Nuclear pseudoinclusions]] (like in ''papillary thyroid carcinoma''). | ||
| Line 383: | Line 390: | ||
*[[Lymphoma]]. | *[[Lymphoma]]. | ||
**[[Burkitt lymphoma]]. | **[[Burkitt lymphoma]]. | ||
*Metastatic small cell carcinoma. | *Metastatic [[small cell carcinoma]]. | ||
*Other [[small round cell tumours]]. | *Other [[small round cell tumours]]. | ||
| Line 522: | Line 529: | ||
Features:<ref name=Ref_Derm521>{{Ref Derm|521}}</ref> | Features:<ref name=Ref_Derm521>{{Ref Derm|521}}</ref> | ||
*S100 -ve (done to r/o melanoma). | *S100 -ve (done to r/o melanoma). | ||
*34betaE12 -ve | *34betaE12 -ve. | ||
*p63 -ve (done to exclude SCC) | |||
**Scant staining not considered +ve. | |||
*Desmin -ve (done to r/o leiomyosarcoma). | *Desmin -ve (done to r/o leiomyosarcoma). | ||