Difference between revisions of "Signet ring cell carcinoma"
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*[http://www.engravingarts.com/sales/LVX2.jpg Signet rings (engravingarts.com)]. | *www: | ||
*[http://commons.wikimedia.org/wiki/File: | **[http://www.engravingarts.com/sales/LVX2.jpg Signet rings (engravingarts.com)]. | ||
*[http://commons.wikimedia.org/wiki/File:Gastric_signet_ring_cell_carcinoma_histopatholgy_( | *[[WC]]: | ||
*[http://commons.wikimedia.org/wiki/File:Gastric_signet_ring_cell_carcinoma_histopatholgy_( | **[http://commons.wikimedia.org/wiki/File:Signet_ring_cell_carcinoma_-_low_mag.jpg SRCC - low mag. - demonstrating that it can be subtle (WC/Nephron)]. | ||
**[http://commons.wikimedia.org/wiki/File:Signet_ring_cell_carcinoma_-_high_mag.jpg SRCC - high mag. (WC/Nephron)]. | |||
**[http://commons.wikimedia.org/wiki/File:Signet_ring_cells_5.jpg SRCC metastasis (WC/Nephron)]. | |||
**[http://commons.wikimedia.org/wiki/File:Gastric_signet_ring_cell_carcinoma_histopatholgy_(1).jpg SRC (WC/KGH)]. | |||
**[http://commons.wikimedia.org/wiki/File:Gastric_signet_ring_cell_carcinoma_histopatholgy_(2)_PAS_stain.jpg SRCC - PAS stain (WC/KGH)]. | |||
==Stains== | ==Stains== | ||
Revision as of 00:39, 4 July 2012
Signet ring cell carcinoma, abbreviated SRCC, is a type of malignant epithelial neoplasm that typically arises from the stomach.
General
- It has been said that there are two types of pathologists... those that have missed SRCCs and those that will miss SRCCs.
Differential diagnosis
It may arise from the:[1]
Microscopic
Features:
- Signet ring cells resemble signet rings.
- They contain a large amount of mucin, which pushes the nucleus to the cell periphery.
- The pool of mucin in a signet ring cell mimics the appearance of the finger hole.
- The nucleus mimics the appearance of the face of the ring in profile.
- Signet ring cells are typically 2-3x the size of a lymphocyte.
- Smaller than the typical adipocyte.
- Often have a crescent-shaped or ovoid nucleus.
- Capillaries sectioned on their lumen have endothelial cells - the nuclei of these are more spindled.
Note:
- SRCs are usually close to friend, i.e. they are adjacent to another SRC.
- This helps differentiate SRCs from capillaries sectioned on their lumen.
- The mucin is often clear on H&E... but maybe eosinophilic.
DDx:
- Serous fat atrophy.[2]
- Mucocele - muciphages may mimic signet ring cells.[3]
Images:
- www:
- WC:
.jpg){kind=link}
_PAS_stain.jpg){kind=link}
Stains
- PAS stain +ve.
- Alican blue-PAS stain +ve.
IHC
- AE1/AE3 +ve.
- CK7 +ve.
See also
References
- ↑ URL: http://cancerhelp.cancerresearchuk.org/about-cancer/cancer-questions/what-is-a-signet-cell-cancer. Accessed on: 7 March 2012.
- ↑ Clarke, BE.; Brown, DJ.; Xipell, JM. (Jan 1983). "Gelatinous transformation of the bone marrow.". Pathology 15 (1): 85-8. PMID 6222282.
- ↑ De Petris, G.; Lev, R.; Siew, S. (May 1998). "Peritumoral and nodal muciphages.". Am J Surg Pathol 22 (5): 545-9. PMID 9591723.