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Difference between revisions of "Melanocytic lesions"
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→Clark nevus: tweak, expand
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(→Clark nevus: tweak, expand) |
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==Clark nevus== | ==Clark nevus== | ||
*[[AKA]] '' | *[[AKA]] ''dysplastic nevus''. | ||
*[[AKA]] ''dysplastic melanocytic nevus''. | |||
===General=== | ===General=== | ||
* | *Benign. | ||
*Clark nevi are | *Clark nevi are considered a risk factor for melanoma and may be precursor of ''[[melanoma]]'', as the name ''dysplastic nevus'' suggests.<ref name=pmid21308311>{{Cite journal | last1 = Rezze | first1 = GG. | last2 = Leon | first2 = A. | last3 = Duprat | first3 = J. | title = Dysplastic nevus (atypical nevus). | journal = An Bras Dermatol | volume = 85 | issue = 6 | pages = 863-71 | month = Dec | year = 2010 | doi = | PMID = 21308311 }}</ref> | ||
**Most melanoma cases do not have evidence of a pre-existing nevus.<ref name=pmid21715047>{{Cite journal | last1 = Longo | first1 = C. | last2 = Rito | first2 = C. | last3 = Beretti | first3 = F. | last4 = Cesinaro | first4 = AM. | last5 = Piñeiro-Maceira | first5 = J. | last6 = Seidenari | first6 = S. | last7 = Pellacani | first7 = G. | title = De novo melanoma and melanoma arising from pre-existing nevus: in vivo morphologic differences as evaluated by confocal microscopy. | journal = J Am Acad Dermatol | volume = 65 | issue = 3 | pages = 604-14 | month = Sep | year = 2011 | doi = 10.1016/j.jaad.2010.10.035 | PMID = 21715047 }}</ref> | |||
*Large numbers of these nevi (10-100) are seen in ''dysplastic nevus syndrome''.<ref name=omim155600>{{OMIM|155600}}</ref> | *Large numbers of these nevi (10-100) are seen in ''dysplastic nevus syndrome''.<ref name=omim155600>{{OMIM|155600}}</ref> | ||
**Individual with this syndrome have an increased risk of melanoma and approximately one third of their melanomas arise from a ''Clark nevus''. The other two thirds arise ''de novo''. | **Individual with this syndrome have an increased risk of melanoma and approximately one third of their melanomas arise from a ''Clark nevus''. The other two thirds arise ''de novo''. | ||
Clinical:<ref name=pmid22220461>{{Cite journal | last1 = Dediol | first1 = I. | last2 = Bulat | first2 = V. | last3 = Zivković | first3 = MV. | last4 = Marković | first4 = BM. | last5 = Situm | first5 = M. | title = Dysplastic nevus--risk factor or disguise for melanoma. | journal = Coll Antropol | volume = 35 Suppl 2 | issue = | pages = 311-3 | month = Sep | year = 2011 | doi = | PMID = 22220461 }}</ref> | |||
*Associated with sun exposure. | |||
===Gross=== | |||
Features:<ref name=pmid22220461/> | |||
*"Ugly duckling sign" - lesion looks different than the rest. | |||
*ABCDE criteria of in melanoma. | |||
===Microscopic=== | ===Microscopic=== | ||