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Difference between revisions of "Endometrial carcinoma"
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→Serous carcinoma of the endometrium
(→Serous carcinoma of the endometrium: +alt. terms) |
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| Line 128: | Line 128: | ||
===Microscopic=== | ===Microscopic=== | ||
Features - serous: | Features - serous: | ||
*Architecture | *Architecture - classically papillary. | ||
**May be glomeruloid, tubulocystic, solid (uncommon). | |||
* | |||
*Cytology: | *Cytology: | ||
**Columnar cells. | **Columnar or cuboidal cells. | ||
** | **#Moderate to marked nuclear pleomorphism - variation of size, shape and staining. | ||
*[[Psammoma bodies]]. | **#*Large nuclear size variation between cells often esp. prominent. | ||
**#Singular prominent, classically red, [[red nucleolus|nucleolus]]. | |||
*+/-[[Psammoma bodies]]. | |||
DDx: | DDx: | ||
*High-grade [[endometrioid endometrial carcinoma]]. | *High-grade [[endometrioid endometrial carcinoma]] - uncommon, typically younger age. | ||
*[[Clear cell carcinoma of the endometrium]] - | *[[Clear cell carcinoma of the endometrium]] - usually have less nuclear pleomorphism and less mitoses. | ||
Images: | |||
*[http://commons.wikimedia.org/wiki/File:Uterine_papillary_serous_carcinoma_low_mag.jpg Uterine serous carcinoma - low mag. (WC)]. | |||
*[http://commons.wikimedia.org/wiki/File:Uterine_serous_carcinoma_high_mag.jpg Uterine serous carcinoma - high mag. (WC)]. | |||
===IHC=== | ===IHC=== | ||
*p16 +ve.<ref name=pmid17581420>{{Cite journal | last1 = Chiesa-Vottero | first1 = AG. | last2 = Malpica | first2 = A. | last3 = Deavers | first3 = MT. | last4 = Broaddus | first4 = R. | last5 = Nuovo | first5 = GJ. | last6 = Silva | first6 = EG. | title = Immunohistochemical overexpression of p16 and p53 in uterine serous carcinoma and ovarian high-grade serous carcinoma. | journal = Int J Gynecol Pathol | volume = 26 | issue = 3 | pages = 328-33 | month = Jul | year = 2007 | doi = 10.1097/01.pgp.0000235065.31301.3e | PMID = 17581420 }}</ref> | *p16 +ve.<ref name=pmid17581420>{{Cite journal | last1 = Chiesa-Vottero | first1 = AG. | last2 = Malpica | first2 = A. | last3 = Deavers | first3 = MT. | last4 = Broaddus | first4 = R. | last5 = Nuovo | first5 = GJ. | last6 = Silva | first6 = EG. | title = Immunohistochemical overexpression of p16 and p53 in uterine serous carcinoma and ovarian high-grade serous carcinoma. | journal = Int J Gynecol Pathol | volume = 26 | issue = 3 | pages = 328-33 | month = Jul | year = 2007 | doi = 10.1097/01.pgp.0000235065.31301.3e | PMID = 17581420 }}</ref> | ||
*p53 +ve > 50% ''or'' 75%% of the tumour. | *p53 +ve<ref name=pmid19623034>{{Cite journal | last1 = Yemelyanova | first1 = A. | last2 = Ji | first2 = H. | last3 = Shih | first3 = IeM. | last4 = Wang | first4 = TL. | last5 = Wu | first5 = LS. | last6 = Ronnett | first6 = BM. | title = Utility of p16 expression for distinction of uterine serous carcinomas from endometrial endometrioid and endocervical adenocarcinomas: immunohistochemical analysis of 201 cases. | journal = Am J Surg Pathol | volume = 33 | issue = 10 | pages = 1504-14 | month = Oct | year = 2009 | doi = 10.1097/PAS.0b013e3181ac35f5 | PMID = 19623034 }}</ref> > 50% ''or'' 75%% of the tumour - depending on the paper one reads. | ||
*ER often -ve.<ref name=pmid10786803>{{Cite journal | last1 = Kounelis | first1 = S. | last2 = Kapranos | first2 = N. | last3 = Kouri | first3 = E. | last4 = Coppola | first4 = D. | last5 = Papadaki | first5 = H. | last6 = Jones | first6 = MW. | title = Immunohistochemical profile of endometrial adenocarcinoma: a study of 61 cases and review of the literature. | journal = Mod Pathol | volume = 13 | issue = 4 | pages = 379-88 | month = Apr | year = 2000 | doi = 10.1038/modpathol.3880062 | PMID = 10786803 }}</ref> | |||
*PR often -ve.<ref name=pmid10786803/> | |||
==Clear cell carcinoma of the endometrium== | ==Clear cell carcinoma of the endometrium== | ||