Difference between revisions of "Neurodegenerative diseases"

Neurodegenerative diseases (view source)

404 bytes added , 20:39, 27 April 2012

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 *Diagnosis is clinical & pathologic.
 **Pathologic finding alone are not diagnostic.
-*[[Trisomy 21]] (Down syndrome) - increases risk.<ref>{{Cite journal  | last1 = Nieuwenhuis-Mark | first1 = RE. | title = Diagnosing Alzheimer's dementia in Down syndrome: problems and possible solutions. | journal = Res Dev Disabil | volume = 30 | issue = 5 | pages = 827-38 | month =  | year =  | doi = 10.1016/j.ridd.2009.01.010 | PMID = 19269132 }}
-</ref>
 *Seen in conjunction with vascular amyloid deposition; see ''[[cerebral amyloid angiopathy]]''.
+Genes associated with Alzheimer disease:<ref>{{Ref PCPBoD8|674-5}}</ref>
+*Amyloid precursor protein (APP).
+**On chromosome 21 - may explain by [[Trisomy 21]] (Down syndrome) - increases the risk.<ref name=pmid19269132>{{Cite journal  | last1 = Nieuwenhuis-Mark | first1 = RE. | title = Diagnosing Alzheimer's dementia in Down syndrome: problems and possible solutions. | journal = Res Dev Disabil | volume = 30 | issue = 5 | pages = 827-38 | month =  | year =  | doi = 10.1016/j.ridd.2009.01.010 | PMID = 19269132 }}</ref>
+*Presenilin 1 (PSEN1).<ref name=omim104311>{{OMIM|104311}}</ref>
+*Presenilin 2 (PSEN2).<ref name=omim600759>{{OMIM|600759}}</ref>
+*Apolipoprotein E (APOE)<ref name=omim107741>{{OMIM|107741}}</ref> - specifically the ''epsilon-4'' allele.
 ===Gross===
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