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Difference between revisions of "Lung tumours"
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→Small cell carcinoma of the lung: tweak
(→Small cell carcinoma of the lung: tweak) |
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==Small cell carcinoma of the lung== | ==Small cell carcinoma of the lung== | ||
*[[AKA]] ''small cell lung carcinoma'', abbreviated ''SCLC''.<ref name=pmid20943645/> | |||
===General=== | ===General=== | ||
*Strong association with smoking. | *Strong association with smoking. | ||
*Typically treated with chemotherapy. | *Typically treated with chemotherapy. | ||
*Poor prognosis. | |||
On a spectrum of lesions (benign to malignant):<ref name=pmid20943645/> | |||
*[[lung tumourlet|Tumourlet]]. | |||
*[[typical carcinoid|Carcinoid]]. | |||
*[[atypical carcinoid|Atypical carcinoid]]. | |||
*Small cell carinoma/large cell neuroendocrine carcinoma. | |||
Precursor lesion - uncommonly seen: | |||
*Pulmonary neuroendocrine cell hyperplasia.<ref name=pmid20943645>{{Cite journal | last1 = Travis | first1 = WD. | title = Advances in neuroendocrine lung tumors. | journal = Ann Oncol | volume = 21 Suppl 7 | issue = | pages = vii65-71 | month = Oct | year = 2010 | doi = 10.1093/annonc/mdq380 | PMID = 20943645 }}</ref> | |||
===Microscopic=== | ===Microscopic=== | ||
Features: | Features: | ||
*Stippled chromatin. | *Stippled chromatin. | ||
*High NC ratio, scant basophilic cytoplasm. | *High [[NC ratio]], scant basophilic cytoplasm. | ||
*Typically small cells ~2x RBC diameter. | *Typically small cells ~2x RBC diameter. | ||
*+/-Nuclear moulding. | *+/-Nuclear moulding. | ||
*Necrosis. | *Necrosis. | ||
*Mitoses. | *Mitoses. | ||
Notes: | |||
*There should be no nucleolus. | |||
DDx: | DDx: | ||
*Metastatic small cell carcinoma. | *Metastatic [[small cell carcinoma]]. | ||
*[[Lymphoma]]. | *[[Lymphoma]]. | ||
*[[Atypical carcinoid]]. | *[[Atypical carcinoid]]. | ||
*Other [[small round blue cell tumours]]. | *Other [[small round blue cell tumours]]. | ||
*Large cell neuroendocrine carcinoma {LCNEC). | |||
==Malignant mesothelioma== | ==Malignant mesothelioma== | ||