Difference between revisions of "Signet ring cell carcinoma"
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*[[Serous fat atrophy]].<ref name=pmid6222282>{{Cite journal | last1 = Clarke | first1 = BE. | last2 = Brown | first2 = DJ. | last3 = Xipell | first3 = JM. | title = Gelatinous transformation of the bone marrow. | journal = Pathology | volume = 15 | issue = 1 | pages = 85-8 | month = Jan | year = 1983 | doi = | PMID = 6222282 }}</ref> | *[[Serous fat atrophy]].<ref name=pmid6222282>{{Cite journal | last1 = Clarke | first1 = BE. | last2 = Brown | first2 = DJ. | last3 = Xipell | first3 = JM. | title = Gelatinous transformation of the bone marrow. | journal = Pathology | volume = 15 | issue = 1 | pages = 85-8 | month = Jan | year = 1983 | doi = | PMID = 6222282 }}</ref> | ||
*[[Mucocele]] - muciphages may mimic signet ring cells. | *[[Mucocele]] - muciphages may mimic signet ring cells.<ref name=pmid9591723>{{Cite journal | last1 = De Petris | first1 = G. | last2 = Lev | first2 = R. | last3 = Siew | first3 = S. | title = Peritumoral and nodal muciphages. | journal = Am J Surg Pathol | volume = 22 | issue = 5 | pages = 545-9 | month = May | year = 1998 | doi = | PMID = 9591723 }}</ref> | ||
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Revision as of 16:33, 6 April 2012
Signet ring cell carcinoma, abbreviated SRCC, is a type of malignant epithelial neoplasm that typically arises from the stomach.
General
- It has been said that there are two types of pathologists... those that have missed SRCCs and those that will miss SRCCs.
Differential diagnosis
It may arise from the:[1]
Microscopic
Features:
- Signet ring cells resemble signet rings.
- They contain a large amount of mucin, which pushes the nucleus to the cell periphery.
- The pool of mucin in a signet ring cell mimics the appearance of the finger hole.
- The nucleus mimics the appearance of the face of the ring in profile.
- Signet ring cells are typically 2-3x the size of a lymphocyte.
- Smaller than the typical adipocyte.
- Often have a crescent-shaped or ovoid nucleus.
- Capillaries sectioned on their lumen have endothelial cells - the nuclei of these are more spindled.
Note:
- SRCs are usually close to friend, i.e. they are adjacent to another SRC.
- This helps differentiate SRCs from capillaries sectioned on their lumen.
- The mucin is often clear on H&E... but maybe eosinophilic.
DDx:
- Serous fat atrophy.[2]
- Mucocele - muciphages may mimic signet ring cells.[3]
Images:
- Signet rings (engravingarts.com).
- SRCs (H&E) by Nephron (WC).
- SRC AL-PAS stain (WC).
- SRC H&E stain (WC).
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Stains
- PAS stain +ve.
- Alican blue-PAS stain +ve.
IHC
- AE1/AE3 +ve.
- CK7 +ve.
See also
References
- ↑ URL: http://cancerhelp.cancerresearchuk.org/about-cancer/cancer-questions/what-is-a-signet-cell-cancer. Accessed on: 7 March 2012.
- ↑ Clarke, BE.; Brown, DJ.; Xipell, JM. (Jan 1983). "Gelatinous transformation of the bone marrow.". Pathology 15 (1): 85-8. PMID 6222282.
- ↑ De Petris, G.; Lev, R.; Siew, S. (May 1998). "Peritumoral and nodal muciphages.". Am J Surg Pathol 22 (5): 545-9. PMID 9591723.