Difference between revisions of "Signet ring cell carcinoma"

Revision as of 16:31, 6 April 2012

Signet ring cell carcinoma, abbreviated SRCC, is a type of malignant epithelial neoplasm that typically arises from the stomach.

It has been said that there are two types of pathologists... those that have missed SRCCs and those that will miss SRCCs.

It may arise from the:^[1]

Features:

Signet ring cells resemble signet rings.
- They contain a large amount of mucin, which pushes the nucleus to the cell periphery.
- The pool of mucin in a signet ring cell mimics the appearance of the finger hole.
- The nucleus mimics the appearance of the face of the ring in profile.
Signet ring cells are typically 2-3x the size of a lymphocyte.
- Smaller than the typical adipocyte.
Often have a crescent-shaped or ovoid nucleus.
- Capillaries sectioned on their lumen have endothelial cells - the nuclei of these are more spindled.

Note:

SRCs are usually close to friend, i.e. they are adjacent to another SRC.
- This helps differentiate SRCs from capillaries sectioned on their lumen.
The mucin is often clear on H&E... but maybe eosinophilic.

DDx:

Images:

↑ URL: http://cancerhelp.cancerresearchuk.org/about-cancer/cancer-questions/what-is-a-signet-cell-cancer. Accessed on: 7 March 2012.
↑ Clarke, BE.; Brown, DJ.; Xipell, JM. (Jan 1983). "Gelatinous transformation of the bone marrow.". Pathology 15 (1): 85-8. PMID 6222282.

@@ Line 33: / Line 33: @@
 DDx:
 *[[Serous fat atrophy]].<ref name=pmid6222282>{{Cite journal  | last1 = Clarke | first1 = BE. | last2 = Brown | first2 = DJ. | last3 = Xipell | first3 = JM. | title = Gelatinous transformation of the bone marrow. | journal = Pathology | volume = 15 | issue = 1 | pages = 85-8 | month = Jan | year = 1983 | doi =  | PMID = 6222282 }}</ref>
+*[[Mucocele]] - muciphages may mimic signet ring cells.
 Images: