Difference between revisions of "Gynecologic cytopathology"

#*Associated with ''bacterial vaginosis'' - which is caused by ''Gardnerella vaginalis''.<ref name="pmid3493202">{{cite journal |author=Scott TG, Smyth CJ, Keane CT |title=In vitro adhesiveness and biotype of Gardnerella vaginalis strains in relation to the occurrence of clue cells in vaginal discharges |journal=Genitourinary medicine |volume=63 |issue=1 |pages=47–53 |year=1987 |month=February |pmid=3493202 |pmc=1194007 |doi= |url=}}</ref>

#*Associated with ''bacterial vaginosis'' - which is caused by ''Gardnerella vaginalis''.<ref name="pmid3493202">{{cite journal |author=Scott TG, Smyth CJ, Keane CT |title=In vitro adhesiveness and biotype of Gardnerella vaginalis strains in relation to the occurrence of clue cells in vaginal discharges |journal=Genitourinary medicine |volume=63 |issue=1 |pages=47–53 |year=1987 |month=February |pmid=3493202 |pmc=1194007 |doi= |url=}}</ref>

#**''Gardnerella vaginalis'' is a rod gram variable.<ref>{{cite journal |author=Taylor-Robinson D |title=The bacteriology of Gardnerella vaginalis |journal=Scand J Urol Nephrol Suppl |volume=86 |issue= |pages=41–55 |year=1984 |pmid=6399409 |doi= |url=}}</ref>

#**''Gardnerella vaginalis'' is a rod gram variable.<ref>{{cite journal |author=Taylor-Robinson D |title=The bacteriology of Gardnerella vaginalis |journal=Scand J Urol Nephrol Suppl |volume=86 |issue= |pages=41–55 |year=1984 |pmid=6399409 |doi= |url=}}</ref>

#*"Dense" cytoplasm.

#*"Dense" cytoplasm.

#*Nucleus ~2X the size of an intermediate cell nucleus.

#*Nucleus ~2X the size of an intermediate cell nucleus.

#**The presence of endometrial cells on a Pap test on a woman >=40 years old (per Bethesda guidelines) should be noted in the pathology report<ref name=pmid15900572>{{cite journal |author=Thrall MJ, Kjeldahl KS, Savik K, Gulbahce HE, Pambuccian SE |title=Significance of benign endometrial cells in papanicolaou tests from women aged >=40 years |journal=Cancer |volume=105 |issue=4 |pages=207-16 |year=2005 |month=August |pmid=15900572 |doi=10.1002/cncr.21156 |url=}}</ref> - this prompts an endometrial biopsy.

#**The presence of endometrial cells on a Pap test on a woman >=40 years old (per Bethesda guidelines) should be noted in the pathology report<ref name=pmid15900572>{{cite journal |author=Thrall MJ, Kjeldahl KS, Savik K, Gulbahce HE, Pambuccian SE |title=Significance of benign endometrial cells in papanicolaou tests from women aged >=40 years |journal=Cancer |volume=105 |issue=4 |pages=207-16 |year=2005 |month=August |pmid=15900572 |doi=10.1002/cncr.21156 |url=}}</ref> - this prompts an endometrial biopsy.

#***In my humble opinion, reporting benign endometrial cells in premenopausal women is ''not'' evidence-based practise; the practise is driven by lawsuit-paranoia in the USA.

#***In my humble opinion, reporting benign endometrial cells in premenopausal women is ''not'' evidence-based practise; the practise is driven by lawsuit-paranoia in the USA.

#*Cells smaller.

#*Cells smaller.

#*Cytoplasm grey/blue.

#*Cytoplasm grey/blue.

#*+/-"Dirty" background - degenerated cells, inflammatory cells (neutrophils, histiocytes).

#*+/-"Dirty" background - degenerated cells, inflammatory cells (neutrophils, histiocytes).

#**May mimic "dirty" background of tumour, i.e. 'tumour diathesis'.

#**May mimic "dirty" background of tumour, i.e. 'tumour diathesis'.

#**Usually older women.

#**Usually older women.

#Tingible body macrophages:

#Tingible body macrophages:

#*Abundant cytoplasm with vacuolization.  

#*Abundant cytoplasm with vacuolization.  

#*May be seen in the context of chlamydia.

#*May be seen in the context of chlamydia.

#*Intermediate cells with:

#*Intermediate cells with:

#**Cells often described as ''boat-shaped''.

#**Cells often described as ''boat-shaped''.

#**May resemble the lenses of ''coke bottle glasses''.

#**May resemble the lenses of ''coke bottle glasses''.